Invitrogen

BEND2 Polyclonal Antibody

Name: BEND2 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-53022

高级验证

查看其他4个BEND2抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (6)
高级验证 (1)

BEND2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BEND2 Antibody (PA5-53022) in IHC (P)

Immunohistochemical analysis of BEND2 in human testis using BEND2 Polyclonal Antibody (Product # PA5-53022) shows strong nuclear positivity in subset of cells in seminiferous ducts.

BEND2 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

BEND2 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of BEND2 demonstrates antibody specificity. Immunohistochemical analysis of BEND2 using anti-BEND2 Polyclonal Antibody (Product # PA5-53022), shows significant staining of BEND2 in human testis and shows minimal or weak staining in human endometrium tissues. The relative expression levels of BEND2 within each tissue is shown using RNA-Seq. {RE}

Immunogen image

Immunogen Image BEND2 Polyclonal Antibody

产品信息

PA5-53022

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human BEND2. Recombinant protein control fragment (Product #RP-92245).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.10 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2638530

产品详细信息

Immunogen sequence: DQDDASASAC LTPDFALLPL NILVKVDTNT ENSVNTMNRS TLLDSDSGQD SSSSSVCIPP KYGYLGDPKR NVRVLKIHLL AVQNMAKPKQ AACYLVRILF SKEILISSSV DIHLKDSQSL DPNKMAALRE YLATTFPTCD LHEHG

Highest antigen sequence identity to the following orthologs: Mouse - 32%, Rat - 21%.

靶标信息

The BEND2 gene, located on chromosome Xp22.2, encodes a protein that is part of the BEN domain-containing family, which is implicated in chromatin organization and transcriptional regulation. BEND2 is critical in spermatogenesis, particularly in the meiotic phase of germ cell development. Knockout studies in male mice have shown that loss of BEND2 disrupts the transition from zygonema to pachynema, interferes with chromosomal synapsis, and impairs the repair of DNA double-strand breaks, ultimately causing infertility. Additionally, BEND2's interaction with chromatin-associated proteins suggests its role in the formation of transcription-repressor complexes, essential for proper gene expression regulation during meiosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。