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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
The bifunctional apoptosis inhibitor (BFAR) is scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors ('extrinsic pathway') as well as mitochondria-dependent apoptosis ('intrinsic pathway'). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to the anti-apoptotic properties of BFAR. In addition, BFAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. BFAR is also thought to be involved in the regulation of neuronal survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Bifunctional apoptosis regulator; RING finger protein 47
基因别名: 3010001A07Rik; AI666707; AW107665; BAR; BFAR; RNF47
UniProt ID: (Rat) Q5PQN2, (Mouse) Q8R079
Entrez Gene ID: (Rat) 304709, (Mouse) 67118