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Proteintech
BCL6 Monoclonal Antibody (1E6B1), Biotin
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
BIOTIN-66340
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E6B1
Immunogen
BCL6 Fusion Protein Ag15519 (183-532 aa encoded by BC150184)
Conjugate
Biotin
Biotin
Biotin
Form
Liquid
Concentration
0.67 mg/mL
Amount
67 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody only recognize human species.
Immunogen sequence: SLYSGLSTP PASYSMYSHL PVSSLLFSDE EFRDVRMPVA NPFPKERALP CDSARPVPGE YSRPTLEVSP NVCHSNIYSP KETIPEEARS DMHYSVAEGL KPAAPSARNA PYFPCDKASK EEERPSSEDE IALHFEPPNA PLNRKGLVSP QSPQKSDCQP NSPTESCSSK NACILQASGS PPAKSPTDPK ACNWKKYKFI VLNSLNQNAK PEGPEQAELG RLSPRAYTAP PACQPPMEPE NLDLQSPTKL SASGEDSTIP QASRLNNIVN RSMTGSPRSS SESHSPLYMH PPKCTSCGSQ SPQHAEMCLH TAGPTFPEEM GETQSEYSDS SCENGAFFCN ECDCRFSEEA S (183-532 aa encoded by BC150184)
Target Information
Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B cell CLL/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; protein LAZ-3; transcriptional repressor; B-cell CLL/lymphoma 6 spliced short isoform; transcriptional repressor; zinc finger protein 51; unnamed protein product; zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S
Gene Aliases: BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
UniProt ID: (Human) P41182
Entrez Gene ID: (Human) 604
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
intronic transcription regulatory region sequence-specific DNA binding
transcription corepressor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
identical protein binding
sequence-specific DNA binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of cytokine production
regulation of germinal center formation
regulation of immune system process
negative regulation of B cell apoptotic process
cellular response to DNA damage stimulus
negative regulation of cell growth
type 2 immune response
regulation of cell proliferation
regulation of apoptotic process
positive regulation of apoptotic process
regulation of T cell differentiation
positive regulation of regulatory T cell differentiation
regulation of cell differentiation
positive regulation of cell differentiation
negative regulation of transcription, DNA-templated
regulation of inflammatory response
regulation of immune response
positive regulation of lymphocyte activation
regulation of leukocyte cell-cell adhesion
negative regulation of mitotic cell cycle DNA replication
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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