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Proteintech
BCL6 Monoclonal Antibody (1E6B1), Biotin
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产品信息
BIOTIN-66340
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1E6B1
抗原
BCL6 Fusion Protein Ag15519 (183-532 aa encoded by BC150184)
偶联物
形式
Liquid
浓度
0.67 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, store in dark
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody only recognize human species.
Immunogen sequence: SLYSGLSTP PASYSMYSHL PVSSLLFSDE EFRDVRMPVA NPFPKERALP CDSARPVPGE YSRPTLEVSP NVCHSNIYSP KETIPEEARS DMHYSVAEGL KPAAPSARNA PYFPCDKASK EEERPSSEDE IALHFEPPNA PLNRKGLVSP QSPQKSDCQP NSPTESCSSK NACILQASGS PPAKSPTDPK ACNWKKYKFI VLNSLNQNAK PEGPEQAELG RLSPRAYTAP PACQPPMEPE NLDLQSPTKL SASGEDSTIP QASRLNNIVN RSMTGSPRSS SESHSPLYMH PPKCTSCGSQ SPQHAEMCLH TAGPTFPEEM GETQSEYSDS SCENGAFFCN ECDCRFSEEA S (183-532 aa encoded by BC150184)
靶标信息
Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S
基因别名: BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51
UniProt ID: (Human) P41182
Entrez Gene ID: (Human) 604
RNA polymerase II regulatory region sequence-specific DNA binding
intronic transcription regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
sequence-specific DNA binding
metal ion binding
C2H2 zinc finger transcription factor
protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
negative regulation of cell-matrix adhesion
germinal center formation
regulation of germinal center formation
negative regulation of B cell apoptotic process
transcription, DNA-templated
inflammatory response
cellular response to DNA damage stimulus
Rho protein signal transduction
spermatogenesis
negative regulation of cell proliferation
actin cytoskeleton organization
myeloid cell differentiation
B cell differentiation
negative regulation of cell growth
positive regulation of B cell proliferation
positive regulation of histone deacetylation
negative regulation of mast cell cytokine production
negative regulation of Rho protein signal transduction
type 2 immune response
regulation of cell proliferation
regulation of apoptotic process
positive regulation of apoptotic process
regulation of GTPase activity
regulation of memory T cell differentiation
negative regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
negative regulation of isotype switching to IgE isotypes
erythrocyte development
regulation of inflammatory response
regulation of neurogenesis
regulation of immune response
positive regulation of cellular component movement
negative regulation of cellular senescence
