Invitrogen

Bcl-2 Recombinant Rabbit Monoclonal Antibody (JF104-8)

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说明书
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问题与答案
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Bcl-2 Recombinant Rabbit Monoclonal Antibody (JF104-8)

产品信息

MA5-41210

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:5,000-1:20,000
-

免疫组化（石蜡） (IHC (P))

1:1,000-1:5,000
-

免疫细胞化学 (ICC/IF)

1:100-1:200
-

流式细胞分析 (Flow)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JF104-8

抗原

Recombinant protein within human Bcl-2 aa 1-230
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 0.05% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2898964

靶标信息

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; OTTHUMP00000163680; protein phosphatase 1, regulatory subunit 50

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基因别名: AW986256; Bcl-2; BCL2; C430015F12Rik; D630044D05Rik; D830018M01Rik; PPP1R50

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UniProt ID: (Human) P10415, (Mouse) P10417

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Entrez Gene ID: (Human) 596, (Mouse) 12043

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功能
protease binding protein binding transcription factor binding channel activity channel inhibitor activity ubiquitin protein ligase binding identical protein binding protein homodimerization activity sequence-specific DNA binding protein heterodimerization activity BH3 domain binding protein phosphatase 2A binding protein phosphatase binding BH domain binding
参与通路
protein polyubiquitination ossification ovarian follicle development metanephros development branching involved in ureteric bud morphogenesis behavioral fear response B cell homeostasis release of cytochrome c from mitochondria regulation of cell-matrix adhesion lymphoid progenitor cell differentiation B cell lineage commitment response to ischemia renal system process protein dephosphorylation melanin metabolic process regulation of nitrogen utilization apoptotic process humoral immune response cellular response to DNA damage stimulus actin filament organization axonogenesis female pregnancy cell aging male gonad development extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress response to radiation response to toxic substance post-embryonic development response to iron ion response to UV-B response to gamma radiation regulation of gene expression negative regulation of autophagy negative regulation of calcium ion transport into cytosol regulation of glycoprotein biosynthetic process mesenchymal cell development positive regulation of neuron maturation positive regulation of smooth muscle cell migration cell growth peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cochlear nucleus development gland morphogenesis regulation of transmembrane transporter activity negative regulation of ossification positive regulation of cell growth negative regulation of cell growth melanocyte differentiation negative regulation of cell migration positive regulation of B cell proliferation hair follicle morphogenesis axon regeneration regulation of protein stability endoplasmic reticulum calcium ion homeostasis glomerulus development negative regulation of cellular pH reduction negative regulation of myeloid cell apoptotic process T cell differentiation in thymus positive regulation of peptidyl-serine phosphorylation negative regulation of osteoblast proliferation response to cytokine response to nicotine organ growth positive regulation of multicellular organism growth B cell proliferation cellular response to glucose starvation response to drug response to hydrogen peroxide T cell homeostasis negative regulation of apoptotic process positive regulation of catalytic activity CD8-positive, alpha-beta T cell lineage commitment regulation of protein homodimerization activity regulation of protein heterodimerization activity negative regulation of neuron apoptotic process ear development regulation of viral genome replication positive regulation of melanocyte differentiation negative regulation of retinal cell programmed cell death regulation of mitochondrial membrane permeability focal adhesion assembly spleen development thymus development digestive tract morphogenesis oocyte development positive regulation of skeletal muscle fiber development pigment granule organization homeostasis of number of cells within a tissue B cell receptor signaling pathway response to glucocorticoid neuron apoptotic process defense response to virus regulation of mitochondrial membrane potential negative regulation of mitochondrial depolarization regulation of calcium ion transport transmembrane transport intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to organic substance cellular response to hypoxia reactive oxygen species metabolic process extrinsic apoptotic signaling pathway in absence of ligand positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway negative regulation of G1/S transition of mitotic cell cycle negative regulation of reactive oxygen species metabolic process negative regulation of anoikis negative regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway cell morphogenesis response to acid chemical ureteric bud development leukocyte homeostasis kidney development lymphocyte homeostasis T cell lineage commitment immune system development cellular calcium ion homeostasis response to oxidative stress cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation apoptotic mitochondrial changes organ morphogenesis single organismal cell-cell adhesion hemopoiesis B cell differentiation T cell differentiation regulation of protein localization growth regulation of apoptotic process regulation of programmed cell death pigmentation negative regulation of mitotic cell cycle developmental pigmentation regulation of developmental pigmentation positive regulation of developmental pigmentation response to steroid hormone developmental growth regulation of catalytic activity regulation of cell cycle
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