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Invitrogen
CARD14 Polyclonal Antibody
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CARD14 Antibody (PA5-120462) in WB
Western blot analysis of CARD14 in extracts of various cell lines. Samples were incubated with CARD14 Polyclonal antibody (Product # PA5-120462) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-120462
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human CARD14 (NP_001244899.1).
偶联物
形式
Liquid
浓度
2.12 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: HT-29, HeLa. The target is usually found in the following locations: Cytoplasm, Cytoplasm.
Immunogen sequence: SLSLHYSNAL QEKELAASRC RSLQEELYLL KQELQRANMV SSCELELQEQ SLRTASDQES GDEELNRLKE ENEKLRSLTF SLAEKDILEQ SLDEARGSRQ ELVERIHSLR ERAVAAERQR EQYWEEKEQT LLQFQKSKMA CQLYREKVNA LQAQVCELQK ERDQAYSARD SAQREISQSL VEKDSLRRQV FELTDQVCEL RTQLRQLQAE PPGVLKQEAR TREPCPREKQ RLVRMHAICP RDDSDCSLVS STESQLLSDL SATSSRELVD SFRSSSPAPP SQQSLYKRVA EDFGEEPWSF S
靶标信息
Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3) and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 14 is a 1,004 amino acid protein consisting of an N-terminal CARD domain, a central coiled-coil domain and a C-terminal tripartite domain comprised of a PDZ domain, an Src homology 3 domain and a GUK domain with homology to guanylate kinase. CARD 14 is expressed in the placenta where it positively regulates apoptosis. CARD 14 also controls NF-kappaB activation by phosphorylating BCL10, a signaling protein that activates NF-kappaB through the I kappaB kinase complex. Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bcl10-interacting MAGUK protein 2; Bimp2; CARD-containing MAGUK protein 2; Carma 2; caspase recruitment domain family, member 14; Caspase recruitment domain-containing protein 14
基因别名: BIMP2; CARD14; CARMA2; PRP; PSORS2; PSS1
UniProt ID: (Human) Q9BXL6, (Mouse) Q99KF0
Entrez Gene ID: (Human) 79092, (Mouse) 170720, (Rat) 688292
