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CBLB Monoclonal Antibody (2D3A2)

查看其他7个Cbl-b抗体

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CBLB Monoclonal Antibody (2D3A2)

产品信息

66353-1-IG

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:400
-

免疫细胞化学 (ICC/IF)

1:50-1:500
-
产品规格

种属反应

Human, Mouse, Pig, Rat

宿主/亚型

Mouse / IgG3

分类

Monoclonal

类型

Antibody

克隆号

2D3A2

抗原

CBLB Fusion Protein Ag18757 (1-352 aa encoded by BC032851)
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

150 µg

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MANSMNGRN PGGRGGNPRK GRILGIIDAI QDAVGPPKQA AADRRTVEKT WKLMDKVVRL CQNPKLQLKN SPPYILDILP DTYQHLRLIL SKYDDNQKLA QLSENEYFKI YIDSLMKKSK RAIRLFKEGK ERMYEEQSQD RRNLTKLSLI FSHMLAEIKA IFPNGQFQGD NFRITKADAA EFWRKFFGDK TIVPWKVFRQ CLHEVHQISS GLEAMALKST IDLTCNDYIS VFEFDIFTRL FQPWGSILRN WNFLAVTHPG YMAFLTYDEV KARLQKYSTK PGSYIFRLSC TRLGQWAIGY VTGDGNILQT IPHNKPLFQA LIDGSREGFY LYPDGRSYNP DLTGLCEPTP HDH (1-352 aa encoded by BC032851)

靶标信息

This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Casitas B-lineage lymphoma b; Casitas B-lineage lymphoma proto-oncogene b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; E3 ubiquitin-protein ligase CBL-B; RING finger protein 56; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; Signal transduction protein CBL-B; unnamed protein product

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基因别名: ADMIO3; AI429560; AI851073; Cbl-b; CBLB; Nbla00127; RNF56

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UniProt ID: (Human) Q13191, (Rat) Q8K4S7, (Mouse) Q3TTA7

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Entrez Gene ID: (Human) 868, (Pig) 100621690, (Rat) 171136, (Mouse) 208650

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功能
phosphotyrosine binding ubiquitin-protein transferase activity calcium ion binding protein binding zinc ion binding transferase activity receptor tyrosine kinase binding metal ion binding ubiquitin protein ligase activity signal transducer activity ligase activity protein kinase binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity damaged DNA-binding protein ligase metabolite interconversion enzyme
参与通路
positive regulation of T cell anergy T cell anergy NLS-bearing protein import into nucleus immune response signal transduction cell surface receptor signaling pathway protein ubiquitination regulation of signaling regulation of cell adhesion protein catabolic process positive regulation of protein ubiquitination intracellular signal transduction CD4-positive, alpha-beta T cell proliferation negative regulation of epidermal growth factor receptor signaling pathway T cell activation positive regulation of protein catabolic process T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway regulation of postsynaptic neurotransmitter receptor internalization regulation protein catabolic process at postsynapse negative regulation of CD4-positive, alpha-beta T cell proliferation regulation of platelet-derived growth factor receptor-alpha signaling pathway response to gravity response to hormone negative regulation of alpha-beta T cell proliferation
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