Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
CCDC127 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
PA5-32051
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human CCDC127. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: A549.
Predicted reactivity: Mouse (81%), Rhesus Monkey (95%), Bovine (86%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
CCDC127 (Coiled-Coil Domain-Containing 127) is a gene that has been identified as a key regulator of lipid droplet (LD) homeostasis by enhancing the mitochondria-ER contact sites (MERCS). This gene encodes a protein with coiled-coil domains, which facilitate interactions with other proteins and cellular structures. CCDC127 plays a critical role in the formation and maintenance of LDs, which are essential organelles for storing neutral lipids and are involved in lipid metabolism and energy homeostasis. Knockdown and overexpression studies in HeLa cells have shown that CCDC127 positively regulates LD abundance, suggesting its importance in cellular lipid management. Additionally, it has been observed that CCDC127 impacts adipose differentiation, indicating its broader role in lipid biology and potential implications in metabolic diseases. The ability of CCDC127 to modulate MERCS highlights its significance in cellular lipid dynamics and organelle communication.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Coiled-coil domain-containing protein 127
基因别名: CCDC127
UniProt ID: (Human) Q96BQ5
Entrez Gene ID: (Human) 133957
