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Invitrogen

CCR2 Polyclonal Antibody

View all (28) CCR2 (CD192) antibodies

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Product Details

PA5-33393

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

20 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 20 amino acid peptide from 2nd extracellular domain of human CCR2.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2550774

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gorilla (100%) Gibbon (95%) Monkey (90%).

Target Information

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cc-ckr2; CD192 antigen; chemokine (C-C motif) receptor 2; hCG_14621; MCP-1 receptor; Mcp1 receptor; Mcp1r; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor; unnamed protein product

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Gene Aliases: CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD

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UniProt ID: (Human) P41597

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Entrez Gene ID: (Human) 729230

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Function(s)
G-protein coupled receptor activity chemokine receptor activity protein binding C-C chemokine receptor activity cytokine binding C-C chemokine binding CCR2 chemokine receptor binding chemokine (C-C motif) ligand 2 binding chemokine (C-C motif) ligand 12 binding chemokine (C-C motif) ligand 7 binding identical protein binding
Process(es)
blood vessel remodeling dendritic cell chemotaxis regulation of T cell cytokine production positive regulation of T-helper 1 type immune response negative regulation of type 2 immune response cellular calcium ion homeostasis chemotaxis inflammatory response immune response cellular defense response G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration JAK-STAT cascade response to wounding regulation of vascular endothelial growth factor production positive regulation of T cell chemotaxis negative regulation of angiogenesis cytokine-mediated signaling pathway sensory perception of pain calcium-mediated signaling cellular homeostasis positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of tumor necrosis factor production monocyte extravasation T-helper 17 cell chemotaxis negative regulation of eosinophil degranulation regulation of T cell differentiation positive regulation of alpha-beta T cell proliferation regulation of inflammatory response positive regulation of inflammatory response positive regulation of T cell activation positive regulation of synaptic transmission, glutamatergic cell chemotaxis chemokine-mediated signaling pathway cellular response to cytokine stimulus positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages inflammatory response to wounding positive regulation of cold-induced thermogenesis positive regulation of glutamate receptor signaling pathway macrophage migration positive regulation of thymocyte migration positive regulation of monocyte extravasation positive regulation of CD8-positive, alpha-beta T cell extravasation positive regulation of astrocyte chemotaxis positive regulation of hematopoietic stem cell migration
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