Invitrogen

CCR2 Recombinant Rabbit Monoclonal Antibody (SN707)

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说明书
实验方案
问题与答案
技术支持
CCR2 Recombinant Rabbit Monoclonal Antibody (SN707)

产品信息

MA5-41175

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:2,000
-

免疫组化 (IHC)

-
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免疫组化（石蜡） (IHC (P))

1:500
-

流式细胞分析 (Flow)

1:500-1:1,000
-

亲和纯化 (AP)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse

已发表种属

C. elegans, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

SN707

抗原

Synthetic peptide within N-terminal human CCR2
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 0.05% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2898929

靶标信息

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: C-C chemokine receptor type 2; C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR); C-C CKR-2; Cc-ckr2; CCR-2; CD192; CD192 antigen; chemoattractant protein-1 receptor; chemokine (C-C motif) receptor 2; chemokine (C-C) receptor 2; hCG_14621; JE/FIC receptor; MCP-1 receptor; MCP-1-R; Mcp1 receptor; Mcp1r; MIP-1 alphaR; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor

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基因别名: CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R; mJe-r

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UniProt ID: (Human) P41597, (Mouse) P51683

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Entrez Gene ID: (Human) 729230, (Mouse) 12772

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功能
chemokine receptor activity C-C chemokine receptor activity protein kinase binding CCR2 chemokine receptor binding protein homodimerization activity chemokine (C-C motif) ligand 5 binding signal transducer activity G-protein coupled receptor activity protein binding cytokine binding chemokine (C-C motif) ligand 2 binding chemokine (C-C motif) ligand 12 binding chemokine (C-C motif) ligand 7 binding
参与通路
angiogenesis blood vessel remodeling wound healing involved in inflammatory response monocyte chemotaxis positive regulation of T-helper 1 type immune response negative regulation of type 2 immune response chemotaxis inflammatory response immune response humoral immune response cellular defense response signal transduction G-protein coupled receptor signaling pathway regulation of vascular endothelial growth factor production positive regulation of T cell chemotaxis negative regulation of angiogenesis cytokine-mediated signaling pathway sensory perception of pain cellular homeostasis hemopoiesis regulation of cell migration positive regulation of interferon-gamma production positive regulation of interleukin-2 production T-helper 17 cell chemotaxis positive regulation of tumor necrosis factor biosynthetic process apoptotic cell clearance negative regulation of eosinophil degranulation positive regulation of T-helper 1 cell differentiation positive regulation of alpha-beta T cell proliferation positive regulation of inflammatory response positive regulation of T cell activation chemokine-mediated signaling pathway positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages positive regulation of monocyte extravasation positive regulation of CD8-positive, alpha-beta T cell extravasation positive regulation of astrocyte chemotaxis positive regulation of hematopoietic stem cell migration dendritic cell chemotaxis inflammatory response to antigenic stimulus cellular calcium ion homeostasis negative regulation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration JAK-STAT cascade aging response to wounding response to ionizing radiation positive regulation of gene expression negative regulation of cell migration negative regulation of axon extension forebrain development positive regulation of fever generation response to lipopolysaccharide positive regulation of interleukin-6 production defense response to bacterium fat cell differentiation positive regulation of neuron differentiation positive regulation of interleukin-1 beta secretion positive regulation of apoptotic process by virus neuron death positive regulation of cell migration involved in sprouting angiogenesis negative regulation of neural precursor cell proliferation
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