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Invitrogen
CD31 (PECAM-1) Recombinant Rabbit Monoclonal Antibody (7O7K3)
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CD31 (PECAM-1) Antibody (MA5-37858) in IHC (P)
Immunohistochemistry analysis of CD31 (PECAM-1) in paraffin-embedded human thyroid. Samples were incubated with CD31 (PECAM-1) Monoclonal antibody (Product # MA5-37858) using a dilution of 1:2,000 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
MA5-37858
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7O7K3
抗原
Recombinant protein (or fragment)
偶联物
形式
Liquid
浓度
0.55 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: U-937, HUVEC, Jurkat, A-549
Immunogen sequence: AKQMPVEMSR PAVPLLNSNN EKMSDPNMEA NSHYGHNDDV RNHAMKPIND NKEPLNSDVQ YTEVQVSSAE SHKDLGKKDT ETVYSEVRKA VPDAVESRYS RTEGSLDGT
靶标信息
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD31; CD31 antigen; EndoCAM; GPIIA'; PECA1; PECAM-1; Platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule 1
基因别名: C85791; CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1; Pecam; PECAM-1; PECAM1
UniProt ID: (Human) P16284, (Rat) Q3SWT0, (Mouse) Q08481
Entrez Gene ID: (Human) 5175, (Rat) 29583, (Mouse) 18613
platelet degranulation
phagocytosis
cell adhesion
signal transduction
cell recognition
extracellular matrix organization
leukocyte migration
diapedesis
glomerular endothelium development
positive regulation of leukocyte migration
Rho protein signal transduction
regulation of cell migration
negative regulation of actin filament polymerization
response to cytokine
negative regulation of GTPase activity
wound healing
positive regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of peptidyl-tyrosine phosphorylation
