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Invitrogen
CD4/CD25 Polyclonal Antibody
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产品信息
PA5-115412
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human IL2RA(Accession P01589), corresponding to amino acid residues A242-I272.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total IL-2RA/CD25.
靶标信息
The CD4 antigen is involved in the recognition of the type II MHC antigen. It is also a receptor for HIV. It is present on most T helper cells and normal thymocytes. The cytoplasmic portion of CD4 is associated with p56lck tyrosine kinase. CD4 expression is commonly found in human lymph nodes and tonsils. CD44 is a type 1 transmembrane glycoprotein also known as Phagocytic Glycoprotein-1 (pgp-1) and HCAM. CD44 is the receptor for hyaluronate and exists as a large number of different isoforms due to alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells, and erythrocytes is a glycosylated type 1 transmembrane protein. Other isoforms contain glycosaminoglycans and are expressed on hematopoietic and non-hematopoietic cells. CD44 is involved in adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix. CD25: IL2 receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD25; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; CD4 receptor; IL 2 RA; IL 2 receptor; IL 2R; IL 2R subunit alpha; IL-2 receptor alpha subunit; IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha; IL-2R alpha chain; IL-2R subunit alpha; IL2 RA; IL2 RA antibody; IL2 receptor; IL2 receptor subunit alpha; IL2-RA; IL2R subunit alpha; Il2ra antibody; interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain; interleukin-2 receptor alpha chain; interleukin-2 receptor precursor; Interleukin-2 receptor subunit alpha; Interleukin2 receptor subunit alpha; p55; p55 chain; sIL 2R; soluble IL 2 receptor; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T4 surface glycoprotein precursor; TAC antigen; unnamed protein product; W3/25 antigen
基因别名: CD25; CD4; CD4mut; IDDM10; IL2R; IL2RA; IL2RAC; IMD41; IMD79; L3T4; Leu-3; Ly-4; Ly-43; OKT4D; p55; T4; TCGFR; W3/25
UniProt ID: (Human) P01730, (Rat) P05540, (Mouse) P06332, (Human) P01589, (Mouse) P01590, (Rat) P26897
Entrez Gene ID: (Human) 920, (Rat) 24932, (Mouse) 12504, (Human) 3559, (Mouse) 16184, (Rat) 25704
virus receptor activity
transmembrane signaling receptor activity
receptor binding
extracellular matrix structural constituent
protein binding
zinc ion binding
lipid binding
coreceptor activity
immunoglobulin binding
enzyme binding
protein kinase binding
MHC class II protein complex binding
signaling receptor activity
interleukin-16 binding
interleukin-16 receptor activity
MHC class II protein binding
identical protein binding
protein homodimerization activity
protein tyrosine kinase binding
glycoprotein binding
interleukin-2 receptor activity
interleukin-2 binding
drug binding
transmembrane signal receptor
positive regulation of protein phosphorylation
adaptive immune response
immune system process
positive regulation of immune system process
immune response
cell adhesion
signal transduction
cell surface receptor signaling pathway
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of calcium ion transport into cytosol
calcium-mediated signaling
T cell differentiation
macrophage differentiation
response to estradiol
maintenance of protein location in cell
positive regulation of interleukin-2 production
response to vitamin D
positive regulation of kinase activity
helper T cell enhancement of adaptive immune response
interleukin-15-mediated signaling pathway
positive regulation of T cell proliferation
T cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
T cell selection
response to ethanol
positive regulation of monocyte differentiation
positive regulation of protein kinase activity
positive regulation of transcription, DNA-templated
positive regulation of viral entry into host cell
viral entry into host cell
defense response to Gram-negative bacterium
positive regulation of calcium-mediated signaling
regulation of T cell activation
positive regulation of T cell activation
positive regulation of multicellular organismal process
regulation of calcium ion transport
positive regulation of ERK1 and ERK2 cascade
cellular response to granulocyte macrophage colony-stimulating factor stimulus
response to methamphetamine hydrochloride
cellular response to ionomycin
cytokine production
induction by virus of host cell-cell fusion
protein palmitoleylation
positive regulation of peptidyl-tyrosine phosphorylation
inflammatory response to antigenic stimulus
regulation of T cell tolerance induction
regulation of immune system process
apoptotic process
activation-induced cell death of T cells
inflammatory response
Notch signaling pathway
interleukin-2-mediated signaling pathway
positive regulation of activated T cell proliferation
negative regulation of T cell proliferation
T cell homeostasis
positive regulation of T cell differentiation
regulation of T cell homeostatic proliferation
lymphocyte proliferation
negative regulation of lymphocyte proliferation
negative regulation of inflammatory response
activated T cell proliferation
regulation of CD4-positive, alpha-beta T cell proliferation
negative regulation of defense response to virus
negative regulation of immune response
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