Invitrogen

CD40 Monoclonal Antibody (C7)

Name: CD40 Monoclonal Antibody (C7)
Brand: Invitrogen
SKU: MA5-41689

查看其他130个CD40抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

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CD40 Antibody (MA5-41689) in WB

Western blot analysis of CD40 in Rat Thymus lysate. Samples were incubated with monoclonal antibody (Product # MA5-41689) at a dilution of 2 µg/mL.

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Immunogen image

Immunogen Image CD40 Monoclonal Antibody (C7)

产品信息

MA5-41689

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.5-2 µg/mL

免疫组化（石蜡） (IHC (P))

5-20 µg/mL

免疫细胞化学 (ICC/IF)

5-20 µg/mL

产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

抗原

Recombinant protein Tumor Necrosis Factor Receptor Superfamily, Member 5. The antigen corresponds to amino acid range 26-187 of the target protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.05% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2899170

靶标信息

CD40 is a single-chain glycoprotein and a member of the tumor necrosis factor receptor (TNFR) family, exhibiting significant homology to the Hodgkin's disease-associated antigen, CD30. It is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells, as well as some epithelial cells, carcinomas, and lymphoid dendritic cells. Notably, CD40 is present on all B cells except plasma cells. CD40 plays a crucial role in regulating B cell development and maturation, inducing immunoglobulin isotype-switching, and protecting B cells from surface Ig-induced apoptosis when combined with other signals such as IL-4. It promotes proliferation and is essential for T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction between CD40 and its ligand CD154 (gp39) on T cells is vital for T-B cell crosstalk, costimulation, and immune regulation. Adaptor protein TNFR2 interacts with CD40, mediating signal transduction, while the AT-hook transcription factor AKNA is reported to regulate CD40 expression, which may be important for homotypic cell interactions. Additionally, the interaction between CD40 and its ligand is necessary for amyloid-beta-induced microglial activation, suggesting a role in the early pathogenesis of Alzheimer's disease. Two alternatively spliced transcript variants encoding distinct isoforms of CD40 have been identified. Diseases associated with CD40 dysfunction include Type 3 Hyper-IgM immunodeficiency and CD40 ligand deficiency, highlighting its importance in immune and inflammatory responses.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; CD40; CD40 antigen, TNF receptor superfamily member 5; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; Immunoglobulin M; ImmunoglobulinM; MGC9013; sCD40; soluble CD40; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5

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基因别名: Bp50; CD40; CDW40; p50; TNFRSF5

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UniProt ID: (Human) P25942

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Entrez Gene ID: (Human) 958, (Rat) 171369

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功能

antigen binding signal transducer activity receptor activity tumor necrosis factor-activated receptor activity protein binding enzyme binding ubiquitin protein ligase binding transmembrane signal receptor

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