Invitrogen

CD51 (Integrin alpha V) Monoclonal Antibody (RMV-7), Biotin, eBioscience™

Name: CD51 (Integrin alpha V) Monoclonal Antibody (RMV-7), Biotin, eBioscience\u2122
Brand: Invitrogen
SKU: 13-0512-82

8个已发表图片

19 篇参考文献

查看其他26个Integrin alpha V (CD51)抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)
已发表图片 (8)

CD51 (Integrin alpha V) Antibody in Flow Cytometry (Flow)

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CD51 (Integrin alpha V) Antibody (13-0512-82) in Flow

Staining of C57BL/6 bone marrow cells with 0.5 µg of Rat IgG1 kappa Isotype Control Biotin (Product # 13-4301-82) (open histogram) or 0.5 µg of Anti-Mouse CD51 (Integrin alpha V) Biotin (filled histogram) followed by Streptavidin PE (Product # 12-4317-87). Cells in the large scatter population were used for analysis.

CD51 (Integrin alpha V) Antibody in Immunohistochemistry (IHC)

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产品信息

13-0512-82

应用

建议稀释比

已发表文章

免疫组化 (IHC)

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流式细胞分析 (Flow)

1 µg/test

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功能检测 (Functional)

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产品规格

种属反应

Mouse

已发表种属

C. elegans, Human, Mouse

宿主/亚型

Rat / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

RMV-7

偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

4°C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

AB_466477

产品详细信息

Description: The RMV-7 monoclonal antibody reacts with the mouse CD51 molecule, the integrin alpha v chain. This approximately 120 kDa surface molecule non-covalently associates with the beta subunits of the integrin family including beta3 (CD61), beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. Heterodimers of CD51/CD61 are expressed by platelets, T cells and granulocytes and mediate adhesion to fibrinogen, fibronectin, vitronectin and thrombospondin.

Applications Reported: The RMV-7 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The RMV-7 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: alpha v integrin; CD51; CD61; GP3A; GPIIIa; Integrin alpha-V; ITGB3; vitronectin receptor alpha polypeptide (VNRA); Vitronectin receptor subunit alpha; VNR

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基因别名: 1110004F14Rik; 2610028E01Rik; CD51; D430040G12Rik; Itgav

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UniProt ID: (Mouse) P43406

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Entrez Gene ID: (Mouse) 16410

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功能