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Invitrogen
CD89 Monoclonal Antibody (MIP8a), PE
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产品信息
MA5-28107
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
MIP8a
抗原
Recombinant soluble human Fc alpha R
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Lyophilized
浓度
Conc. not determined
纯化类型
purified
保存液
PBS with 1% BSA, 5% sucrose
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes the human CD89 cell surface antigen, a 50-75 kDa cell surface glycoprotein that is also known as the IgA receptor (Fc alpha R). CD89 is expressed by peripheral blood monocytes and neutrophils. MIP8a blocks binding of IgA to the Fc alpha R, and also inhibits neutrophil phagocytosis of IgA complexes.
Reconstitute with 1 mL distilled water.
靶标信息
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD89; Fc fragment of IgA receptor; Fc fragment of IgA, receptor for; IgA Fc receptor; IgA Fc receptor Fc alpha Rla2 variant; Immunoglobulin alpha Fc receptor; unnamed protein product
基因别名: CD89; CTB-61M7.2; FcalphaR; FcalphaRI; FCAR
UniProt ID: (Human) P24071
Entrez Gene ID: (Human) 2204
neutrophil mediated immunity
immune response-regulating signaling pathway
immune response
positive regulation of neutrophil apoptotic process
cellular response to interferon-alpha
Fc receptor signaling pathway
neutrophil activation
cellular response to lipopolysaccharide
cellular response to interferon-gamma
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to granulocyte macrophage colony-stimulating factor stimulus
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