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CDCA4 encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cell division cycle-associated protein 4; FLJ20764; Hematopoietic progenitor protein; MGC19517
基因别名: CDCA4; HEPP; SEI-3/HEPP
UniProt ID: (Human) Q9BXL8
Entrez Gene ID: (Human) 55038