Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

CDK9 Polyclonal Antibody

查看其他24个CDK9抗体

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

产品信息

PA5-85238

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

免疫细胞化学 (ICC/IF)

1:100-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human CDK9. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol, 1% BSA

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2792381

产品详细信息

Keep as concentrated solution.

Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (86%), Xenopus laevis (85%), Pig (98%), Chicken (87%), Rhesus Monkey (100%), Bovine (98%).

Positive Control: HL-60, NIH-3T3.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: C-2K; CDC2-related kinase; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; unnamed protein product

查看更多 收起

基因别名: C-2k; CDC2L4; CDK9; CTK1; PITALRE; TAK

查看更多 收起

UniProt ID: (Human) P50750, (Mouse) Q99J95, (Rat) Q641Z4

查看更多 收起

Entrez Gene ID: (Human) 1025, (Mouse) 107951, (Rat) 362110

查看更多 收起

功能
nucleotide binding transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription coactivator binding DNA binding chromatin binding obsolete transcription elongation regulator activity protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding RNA polymerase II carboxy-terminal domain kinase activity kinase activity transferase activity snRNA binding protein kinase binding 7SK snRNA binding protein serine kinase activity transcription factor binding transferase activity, transferring phosphorus-containing groups transcription regulatory region DNA binding non-receptor serine/threonine protein kinase
参与通路
DNA repair regulation of DNA repair transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter protein phosphorylation cellular response to DNA damage stimulus regulation of mitotic cell cycle cell proliferation replication fork processing regulation of mRNA 3'-end processing positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of transcription elongation from RNA polymerase II promoter positive regulation by host of viral transcription positive regulation of transcription from RNA polymerase II promoter regulation of muscle cell differentiation nucleus localization regulation of cell cycle cellular response to cytokine stimulus negative regulation of protein localization to chromatin positive regulation of protein localization to chromatin transcription elongation-coupled chromatin remodeling transcription pausing by RNA polymerase II transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of cardiac muscle hypertrophy phosphorylation regulation of histone modification positive regulation of histone phosphorylation replication fork arrest negative regulation of cell cycle arrest negative regulation of mRNA polyadenylation positive regulation of mRNA 3'-UTR binding positive regulation of histone H2B ubiquitination response to drug
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持