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Rockland
CEBP delta Polyclonal Antibody
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CEBP delta Antibody (600-401-A61) in WB
Western Blot of Anti-C/EBPd Antibody. Lane 1: untreated wild-type (WT) cells. Lane 2: WT cells treated 3 h with LPS. Lane 3: C/EBPd-knock-out cells treated 3H with LPS. Load: 35 µg per lane. Primary: Anti-C/EBPd Antibody used at a dilution of 1:15k overnight at 4°C. Blocking: buffer TBST. ECL was used for detection of endogenous protein in whole cell extracts from mouse primary macrophage cells. Predicted/Observed size: 28.8 kDa, ~35 kDa.
产品信息
600-401-A61
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to the amino terminus of mouse C/EBP.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
内含物
0.01% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This antibody recognizes endogenous mouse and recombinant human C/EBP delta protein. A BLAST analysis was used to suggest cross-reactivity with C/EBPd from human sources based on 77% homology with the immunizing sequence. No cross-reactivity is observed with mouse C/EBPa or C/EBPb. Reactivity with C/EBPd from other sources has not been determined.
靶标信息
C/EBP delta are CCAAT enhancer binding proteins (CEBPs), a family of transcription factors that all contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in dimerization and DNA binding. At least six members of the family have been isolated and characterized to date (CEBP alpha to CEBP zeta). CEBPD is a leucine zipper (LZ) DNA-binding protein that regulates gene expression in a variety of tissues including liver, adipose, lung and intestine. CEBPD is an important transcriptional activator in the regulation of genes involved in immune and inflammatory responses and has been reported to possess many tumor suppressor-like properties.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C EBP; C/EBP delta; C/EBP-related protein 3; CCAAT/enhancer binding protein (C/EBP), delta; CCAAT/enhancer-binding protein delta; NF-IL6-beta; Nuclear factor NF-IL6-beta
基因别名: C/EBP-delta; CEBPD; CELF; CRP3; NF-IL6-beta
UniProt ID: (Human) P49716, (Mouse) Q00322
Entrez Gene ID: (Human) 1052, (Mouse) 12609
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
basic leucine zipper transcription factor
transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
hematopoietic progenitor cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
fat cell differentiation
positive regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
inner ear development
