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Invitrogen
CHRM3 Polyclonal Antibody
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产品信息
PA1-86940
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide: 3rd cytoplasmic domain of human muscarinic receptor M3, conjugated to KLH.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS
内含物
<0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Predicted to react with mouse based on sequence homology.
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. A suggested positive control for immunohistochemical applications is brain, cortex.
Rabbit anti Human muscarinic receptor M3 antibody detects the muscarinic receptor M3, a G protein-coupled receptor for acetylcholine which is expressed in smooth muscle and glandular tissues.
靶标信息
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetylcholine receptor; acetylcholine receptor, muscarinic 3; cholinergic receptor; cholinergic receptor, muscarinic 3; m3 muscarinic receptor; Muscarinic acetylcholine receptor M3
基因别名: CHRM3; EGBRS; HM3; PBS
UniProt ID: (Human) P20309
Entrez Gene ID: (Human) 1131
regulation of vascular smooth muscle contraction
cellular protein modification process
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
nervous system development
cell proliferation
positive regulation of smooth muscle contraction
saliva secretion
