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Proteintech
CD44 Monoclonal Antibody (6F4H2), CoraLite® Plus 488
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产品信息
CL488-60224
产品规格
种属反应
Human,
Pig
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
6F4H2
抗原
CD44 fusion protein Ag7633
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: CRFAGVFHV EKNGRYSISR TEAADLCKAF NSTLPTMAQM EKALSIGFET CRYGFIEGHV VIPRIHPNSI CAANNTGVYI LTSNTSQYDT YCFNASAPPE EDCTSVTDLP NAFDGPITIT IVNRDGTRYV QKGEYRTNPE DIYPSNPTDD DVSSGSSSER SSTSGGYIFY TFSTVHPIPD EDSPWITDST DRIPATSTSS NTISAGWEPN EENEDERDRH LSFSGSGIDD DEDFISSTIS TTPRAFDHTK QNQDWTQWNP SHSNPEVLLQ TTTRMTDVDR NGTTAYEGNW NPEAHPPLIH HEHHEEEETP HSTSTIQATP SSTTEETATQ KEQWFGNRWH EGYRQTPRED SHST
靶标信息
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD44; CD44 antigen; CD44 molecule; CD44 molecule (Indian blood group); CDw44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; PGP I; PGP-1; PGP-I; PGPI; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44; soluble CD44
基因别名: CD44; CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1
UniProt ID: (Human) P16070
Entrez Gene ID: (Human) 960, (Pig) 100525150
cell-matrix adhesion
single organismal cell-cell adhesion
extracellular matrix disassembly
extracellular matrix organization
hyaluronan catabolic process
positive regulation of peptidyl-serine phosphorylation
positive regulation of heterotypic cell-cell adhesion
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
cellular response to fibroblast growth factor stimulus
positive regulation of peptidyl-tyrosine phosphorylation
leukocyte migration
cartilage development
interferon-gamma-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
monocyte aggregation
positive regulation of monocyte aggregation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
