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CD11b Recombinant Mouse Monoclonal Antibody (OX42), CoraLite® 594
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CD11b Antibody (CL594-65606) in Flow
1x10^6 rat bone marrow cells were surface stained with 0.25 µg CoraLite®594 Anti-Rat CD11b (OX42) Mouse IgG2a Recombinant Antibody (CL594-65606, Clone: OX42) (red), or CoraLite®594 Mouse IgG2a Isotype Control (C1.18.4) (CL594-65208, Clone: C1.18.4) (blue). Cells were not fixed.
产品信息
CL594-65606
产品规格
种属反应
Rat
宿主/亚型
Mouse
/ IgG2a
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
OX42
抗原
Rat peritoneal macrophages
偶联物
CoraLite® 594
CoraLite® 594
CoraLite® 594
激发/发射光谱
593/614 nm
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
4°C, store in dark
运输条件
Wet ice
靶标信息
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
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