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Proteintech
RANGAP1 Monoclonal Antibody (1F3A4), CoraLite® Plus 594
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL594-67146
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F3A4
Immunogen
RANGAP1 fusion protein Ag26136
Conjugate
CoraLite® Plus 594
CoraLite® Plus 594
CoraLite® Plus 594
Excitation/Emission Max
588/604 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: ASEDIAKLAE TLAKTQVAGG QLSFKGKSLK LNTAEDAKDV IKEIEDFDSL EALRLEGNTV GVEAARVIAK ALEKKSELKR CHWSDMFTGR LRTEIPPALI SLGEGLITAG AQLVELDLSD NAFGPDGVQG FEALLKSSAC FTLQELKLNN CGMGIGGGKI LAAALTECHR KSSAQGKPLA LKVFVAGRNR LENDGATALA EAFRVIGTLE EVHMPQNGI
Target Information
Ran is a small signaling GTPase that is involved in nucleocytoplasmic transport. Two additional functions of animal Ran in the formation of spindle asters and the reassembly of the nuclear envelope in mitotic cells have been recently reported. In contrast to Ras or Rho, Ran is not associated with membranes. Instead, the spatial sequestering of its accessory proteins, the Ran GTPase-activating protein RanGAP and the nucleotide exchange factor RCC1, appears to define the local concentration of RanGTP vs. RanGDP involved in signaling. Mammalian RanGAP is bound to the nuclear pore by a mechanism involving the attachment of small ubiquitin-related modifier protein (SUMO) to its C terminus and the subsequent binding of the SUMOylated domain to the nucleoporin Nup358.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homolog of yeast RNA1, RNA production and processing protein, Swiss Prot Accession Number P11745; MGC20266; RANGAP1; segregation distorter homolog; unnamed protein product
Gene Aliases: Fug1; mKIAA1835; RANGAP; SD
UniProt ID: (Human) P46060, (Mouse) P46061
Entrez Gene ID: (Human) 5905, (Mouse) 19387, (Rat) 362965
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