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Invitrogen
CLAC-P Polyclonal Antibody
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产品信息
PA1-4308
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide: D(430) Y N G N L H E A L Q R I T(443) of the NC3 region of human and murine CLAC-P
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-4308 detects CLAC-P (NC3 region) in human and mouse samples.
PA1-4308 has been successfully used in Western blotting and immunohistochemistry procedures. By Western blot, this antibody detects a ~70 kDa protein representing CLAC-P (NC3 region) in stable HEK293T cell lines expressing CLAC-P (NC3 region). PA1-4308 does not cross react with COLXIII or COLXXIII proteins.
PA1-4308 immunizing peptide corresponds to amino acid residues 430-443 of the NC3 region of human and mouse CLAC-P.
Maintain at 4°C for 3 months or at -20°C for longer periods. Avoid freeze/thaw cycles.
靶标信息
Alzheimer's disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (A beta). Although production and deposition of A beta appear closely related to the pathogenesis of AD, current evidence suggest that A beta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alzheimer disease amyloid-associated protein; AMY; CLAC-P; col25a1; Collagen alpha-1(XXV) chain; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component; procollagen, type XXV, alpha 1
基因别名: 2700062B08Rik; AMY; CFEOM5; CLAC; CLAC-P; CLACP; COL25A1
UniProt ID: (Human) Q9BXS0, (Mouse) Q99MQ5
Entrez Gene ID: (Human) 84570, (Mouse) 77018
