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Invitrogen
CLCNKA Polyclonal Antibody
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CLCNKA Antibody (PA5-92064) in WB
Western blot analysis of CLCNKA in extracts of various cell lines. Samples were incubated with CLCNKA Polyclonal antibody (Product # PA5-92064) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-92064
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 470-644 of human CLCNKA (NP_0012440681)
偶联物
形式
Liquid
浓度
0.18 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: QSCQPSFYDG TIIVKKLPYL PRILGRNIGS HHVRVEHFMN HSITTLAKDT PLEEVVKVVT STDVTEYPLV ESTESQILVG IVQRAQLVQA LQAEPPSRAP GHQQCLQDIL ARGCPTEPVT LTLFSETTLH QAQNLFKLLN LQSLFVTSRG RAVGCVSWVE MKKAISNLTN PPAPK; Positive Samples: LO2, HT-29, A-549; Cellular Location: Membrane, Multi-pass membrane protein
靶标信息
CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter's syndrome which is characterized by renal salt-wasting and low blood pressure.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: chloride channel K1; Chloride channel Ka; Chloride channel protein ClC-Ka; chloride channel, kidney, A; chloride channel, voltage-sensitive Ka; ClC-K1; CLC-KA; CLCKA; putative basolateral cTAL chloride channel ClC-Ka
基因别名: C75963; CLC-K1; CLCK1; Clcnk1; CLCNKA; hClC-Ka
UniProt ID: (Human) P51800, (Mouse) Q9WUB7
Entrez Gene ID: (Human) 1187, (Mouse) 12733
