Invitrogen

CLSTN1 Polyclonal Antibody

Name: CLSTN1 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-109556

查看其他13个CLSTN1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

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CLSTN1 Antibody (PA5-109556) in WB

Western blot analysis of CLSTN1 in extracts of various cell lines. Samples were incubated with CLSTN1 Polyclonal antibody (Product # PA5-109556) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

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Immunogen image

Immunogen Image CLSTN1 Polyclonal Antibody

产品信息

PA5-109556

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200-1:2,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 29-350 of human CLSTN1 (NP_055759.3).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.04 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2854967

产品详细信息

Immunogen sequence: ARVNKHKPWL EPTYHGIVTE NDNTVLLDPP LIALDKDAPL RFAGEICGFK IHGQNVPFDA VVVDKSTGEG VIRSKEKLDC ELQKDYSFTI QAYDCGKGPD GTNVKKSHKA TVHIQVNDVN EYAPVFKEKS YKATVIEGKQ YDSILRVEAV DADCSPQFSQ ICSYEIITPD VPFTVDKDGY IKNTEKLNYG KEHQYKLTVT AYDCGKKRAT EDVLVKISIK PTCTPGWQGW NNRIEYEPGT GALAVFPNIH LETCDEPVAS VQATVELETS HIGKGCDRDT YSEKSLHRLC GAAAGTAELL PSPSGSLNWT MGLPTDNGHD SD

靶标信息

CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。