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Invitrogen
COL4A3 Polyclonal Antibody
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COL4A3 Antibody (PA5149822) in IHC (P)
Immunohistochemistry analysis of COL4A3 in paraffin-embedded Human Stomach tissue. Samples were incubated with COL4A3 Polyclonal (Product # PA5149822) antibody using a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
产品信息
PA5149822
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant Collagen Type IV Alpha 3 (COL4a3) (Leu1428-His1670)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: col4a3; collagen alpha-3; Collagen alpha-3(IV) chain; collagen IV, alpha-3 polypeptide; collagen type IV alpha3 chain; collagen, type IV, alpha 3 (Goodpasture antigen); Goodpasture antigen; IV chain; procollagen, type IV, alpha 3; tumstatin
基因别名: [a]3(IV); alpha3(IV); COL4A3
UniProt ID: (Human) Q01955, (Mouse) Q9QZS0
Entrez Gene ID: (Human) 1285, (Mouse) 12828
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell adhesion
cell surface receptor signaling pathway
sensory perception of sound
blood circulation
cell proliferation
negative regulation of cell proliferation
negative regulation of endopeptidase activity
negative regulation of angiogenesis
extracellular matrix organization
collagen catabolic process
glomerular basement membrane development
endothelial cell apoptotic process
