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Abnova
COP1 Polyclonal Antibody, MaxPab™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00114769-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
COP1 (NP_443121.1, 1 a.a. approximately 97 a.a) full-length human protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.43 mg/mL
规格
50 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MADKVLKEKR KLFIHSMGEG TINGLLDELL QTRVLNQEEM EKVKRENATV MDKTRALIDS VIPKGAQACQ ICITYICEED SYLAETLGLS AGPIPGN
靶标信息
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARABIDOPSIS THALIANA CONSTITUTIVE PHOTOMORPHOGENIC 1; ATCOP1; CARD only domain-containing protein 1; CARD only protein; CARD-only protein 1; Caspase recruitment domain-containing protein 16; Caspase recruitment domain-only protein 1; caspase-1 dominant-negative inhibitor pseudo-ICE; Caspase-1 inhibitor COP; CONSTITUTIVE PHOTOMORPHOGENIC 1; DEETIOLATED MUTANT 340; DET340; EMB168; EMBRYO DEFECTIVE 168; FUS1; FUSCA 1; Pseudo interleukin-1 beta converting enzyme; pseudo interleukin-1beta converting enzyme; Pseudo-ICE; pseudo-IL1B-converting enzyme; T21L14.11; T21L14_11; unnamed protein product
基因别名: CARD16; COP; COP1; LLID-114769; PSEUDO-ICE
UniProt ID: (Human) Q5EG05
Entrez Gene ID: (Human) 114769
proteolysis
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of protein binding
regulation of interleukin-1 beta production
negative regulation of interleukin-1 beta production
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of NF-kappaB transcription factor activity
cellular response to lipopolysaccharide
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