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Agrisera
CPX1/coproporphyrinogen III oxidase, isoform 1 Polyclonal Antibody
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产品信息
AS06-123
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Residues 32-366 from mature coproporphyrinogen III oxidase, isoform CPX1 of Chlamydomonas reinhardtii fused to TrxA.
偶联物
形式
Lyophilized
保存液
whole serum
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 100 µL of sterile water.
Specific Species Reactivity: Physcomitrium patens
靶标信息
CPX1 isoform 1 encodes a small, soluble, predominantly cytosolic presynaptic protein that is enriched in neurons and associates with sites of synaptic vesicle exocytosis through high-affinity binding to assembled/assembling SNARE complexes. Isoform 1 is a ~134 amino-acid protein organized into functionally specialized helical regions, including an N-terminal segment that promotes Ca2+-evoked neurotransmitter release, an accessory alpha-helix that contributes to suppression of premature/spontaneous fusion by restraining late SNARE "zippering," and a conserved central alpha-helix that forms the core SNARE-binding interface; its C-terminal region further supports membrane- and fusion-site engagement to tune complexin access to assembling SNAREs. Functionally, CPX1 acts as a bidirectional regulator of synaptic transmission by stabilizing an intermediate SNAREpin state that both primes vesicles for fast, Ca2+-triggered fusion and clamps fusion to limit spontaneous release, thereby sharpening the timing and reliability of neurotransmitter secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CPX-I; CPX1; CPXM; DEE63; EIEE63
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