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Rockland
CRIM2 Polyclonal Antibody
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产品信息
600-401-AN4
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-CRIM2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the C-terminus of human CRIM2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-Beta1, suppressing activin- and TGF-Beta1-dependent transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CRIM-2; cysteine rich BMP regulator 2 (chordin like); cysteine rich BMP regulator 2 (chordin-like); Cysteine-rich BMP regulator 2; Cysteine-rich motor neuron 2 protein; KCP-1; kielin; Kielin/chordin-like protein; Kielin/chordin-like protein 1
基因别名: AW060220; CRIM-2; CRIM2; Gm793; KCP; KCP-1; KCP1; NET67; RGD1561119
UniProt ID: (Human) Q6ZWJ8, (Mouse) Q3U492
Entrez Gene ID: (Human) 375616, (Rat) 296952, (Mouse) 333088
