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The CRYGF gene, part of the gammacrystallin gene family, is critical for maintaining lens transparency in the eye. Located on mouse chromosome 1, the CRYGF gene, along with its related gammacrystallin counterparts, contributes significantly to lens function and clarity. Mutations within this gene can lead to cataracts, a clouding of the lens, and are thus crucial for understanding hereditary cataract formation. The dominant mutation known as Crygf(Rop) has been identified, underscoring the gene's role in lens transparency and highlighting the genetic and allelic heterogeneity present within the gammacrystallin family. Although fewer mutations have been discovered in CRYGF compared to other gammacrystallins, its importance remains substantial in the lens' structural integrity and optical properties.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CRYGF; crystallin, gamma polypeptide 6; gamma-crystallin 4-1; Gamma-crystallin F; Gamma-F-crystallin
基因别名: 3110001K11Rik; Cryg-2; Cryg6; Crygf; DGcry-2; Len; Len-2
UniProt ID: (Mouse) Q9CXV3
Entrez Gene ID: (Rat) 689947, (Mouse) 12969