Invitrogen

CYP1B1 Polyclonal Antibody

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说明书
实验方案
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技术支持
CYP1B1 Polyclonal Antibody

产品信息

PA5-95277

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL
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免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL
-

流式细胞分析 (Flow)

1-3 µg/1x10^6 cells
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

C. elegans, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E.coli-derived human CYP1B1 recombinant protein (Position: R255-L480).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5mg BSA

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2807081

产品详细信息

Human CYP1B1 shares 85.4% and 84.5% amino acid (aa) sequence identity with mouse and rat CYP1B1, respectively.

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human MCF-7 whole cell, human PC-3 whole cell, rat heart tissue, mouse heart tissue. IHC: Mouse Kidney tissue, Rat Kidney tissue, Human Liver Cancer tissue. Flow: SiHa cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

靶标信息

CYP1B1 is a 543 amino acid intracellular protein localized to the endoplasmic reticulum. It belongs to the cytochrome P450 super family of enzymes which are monooxygenases and it catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol and is also involved in the metabolism of substances active in the eye growth and differentiation and hence plays a putative role in ocular development. Mutated proteins are known to cause primary congenital glaucoma.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: aryl hydrocarbon hydroxylase; benz[a]anthracene inducible; CYPIB1; Cytochrome P450 1B1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily 1B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); Cytochrome P450CMEF; Cytochrome P450EF; Cytochrome P450RAP; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P450RAP; xenobiotic monooxygenase

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基因别名: CP1B; Cyp1-b1; CYP1B1; CYPIB1; GLC3A; P4501B1

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UniProt ID: (Human) Q16678, (Rat) Q64678, (Mouse) Q64429

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Entrez Gene ID: (Human) 1545, (Rat) 25426, (Mouse) 13078

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功能
monooxygenase activity iron ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen oxygen binding heme binding aromatase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding oxidoreductase oxygenase metabolite interconversion enzyme
参与通路
angiogenesis trabecular meshwork development cellular aromatic compound metabolic process xenobiotic metabolic process nitric oxide biosynthetic process cell adhesion visual perception steroid metabolic process estrogen metabolic process negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to oxidative stress toxin metabolic process response to toxic substance positive regulation of vascular endothelial growth factor production sterol metabolic process arachidonic acid metabolic process epoxygenase P450 pathway collagen fibril organization negative regulation of cell migration negative regulation of NF-kappaB transcription factor activity negative regulation of cell adhesion mediated by integrin retinol metabolic process retinal metabolic process positive regulation of apoptotic process endothelial cell migration positive regulation of angiogenesis positive regulation of JAK-STAT cascade membrane lipid catabolic process blood vessel morphogenesis oxidation-reduction process retinal blood vessel morphogenesis cellular response to hydrogen peroxide cellular response to organic cyclic compound endothelial cell-cell adhesion omega-hydroxylase P450 pathway regulation of reactive oxygen species metabolic process DNA modification response to nutrient male gonad development response to organic substance response to organic cyclic compound positive regulation of smooth muscle cell migration dibenzo-p-dioxin metabolic process adrenal gland development response to follicle-stimulating hormone response to estradiol benzene-containing compound metabolic process estrous cycle positive regulation of translation response to arsenic-containing substance response to steroid hormone retina vasculature development in camera-type eye ganglion development cellular response to cAMP cellular response to tumor necrosis factor cellular response to luteinizing hormone stimulus cellular response to cortisol stimulus cellular response to progesterone stimulus response to dexamethasone response to indole-3-methanol positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process
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