Invitrogen

CYP3A4 Monoclonal Antibody (3H8)

Name: CYP3A4 Monoclonal Antibody (3H8)
Brand: Invitrogen
SKU: MA5-17064

高级验证

3个已发表图片

9 篇参考文献

查看其他11个CYP3A4抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

CYP3A4 Antibody in Immunocytochemistry (ICC/IF)

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CYP3A4 Antibody (MA5-17064) in ICC/IF

Immunofluorescence analysis of HepG2 cells using CYP3A4 monoclonal antibody (Product # MA5-17064) (Green). Blue: DRAQ5 fluorescent DNA dye. Red: actin filaments have been labeled with phalloidin.

CYP3A4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CYP3A4 Antibody in Flow Cytometry (Flow)

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产品信息

MA5-17064

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:200-1:1000

免疫细胞化学 (ICC/IF)

1:200-1:1000

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流式细胞分析 (Flow)

1:200-1:400

酶联免疫吸附实验 (ELISA)

1:10,000

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产品规格

种属反应

Human

已发表种属

C. elegans, Human, Yeast

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

3H8

抗原

Purified recombinant fragment of human CYP3A4 expressed in E. Coli.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2538535

产品详细信息

MA5-17064 targets CYP3A4 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples.

The MA5-17064 immunogen is purified recombinant fragment of human CYP3A4 expressed in E. Coli.

MA5-17064 detects CYP3A4 which has a predicted molecular weight of approximately 57.3kDa.

靶标信息

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; Albendazole monooxygenase (sulfoxide-forming); Albendazole sulfoxidase; Cholesterol 25-hydroxylase; CYP; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 3A4; Cytochrome P450 HLp; Cytochrome P450 NF-25; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; Cytochrome P450-PCN1; glucocorticoid-inducible P450; MGC126680; Nifedipine oxidase; P450; P450-III, steroid inducible; P450-PCN1; Quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

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基因别名: CP33; CP34; CYP3A; CYP3A3; CYP3A4; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1

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UniProt ID: (Human) P08684

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Entrez Gene ID: (Human) 1576

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功能