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Invitrogen
Calcium Sensing Receptor Monoclonal Antibody (5C10, ADD)
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Calcium Sensing Receptor Antibody (MA1-934) in IHC (P)
Immunohistochemistry was performed on normal biopsies of deparaffinized Human kidney tissue. To expose target proteins, heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes. Following antigen retrieval tissues were blocked in 3% BSA-PBS for 30 minutes at room temperature. Tissues were then probed at a dilution of 1:100 with a mouse monoclonal ant... View More
产品信息
MA1-934
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat
已发表种属
C. elegans,
Human,
Mouse,
Pig,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
5C10, ADD
抗原
Synthetic peptide corresponding to residues (214) A D D D Y G R P G I E K F RE E A E E R D I (235) of human calcium sensing receptor.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-934 detects human, bovine, mouse, and rat calcium sensing receptor.
MA1-934 has been successfully used in Western blot, immunohistochemistry, and ELISA procedures. By Western blot, this antibody detects an ~ 150 and 130 kDa proteins from human HEK-293 cells.This antibody has also been used in immunohistochemical on frozen bovine parathyroid gland and rat thyroid gland.
The MA1-934 immunogen is a synthetic peptide corresponding to residues (214) A D D D Y G R P G I E K F RE E A E E R D I (235) of human calcium sensing receptor.
靶标信息
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BoPCaR1; Ca sensing receptor; calcium-sensing receptor; Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism); Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism); CaR; CaSR; CaSR antibody; cation sensing receptor; Extracellular calcium-sensing receptor; G protein coupled receptor, family C, group 2, member A; G protein-coupled receptor, family C, group 2, member A; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; Parathyroid cell calcium-sensing receptor 1; PCaR1
基因别名: BoPCaR1; CAR; CASR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1
UniProt ID: (Bovine) P35384, (Human) P41180, (Rat) P48442, (Mouse) Q9QY96
Entrez Gene ID: (Bovine) 281038, (Human) 846, (Rat) 24247, (Mouse) 12374
G-protein coupled receptor activity
calcium ion binding
protein binding
amino acid binding
protein homodimerization activity
phosphatidylinositol phospholipase C activity
magnesium ion binding
integrin binding
drug binding
polyamine binding
protein kinase binding
ion channel binding
signal transducer activity
G-protein coupled receptor
ossification
detection of calcium ion
calcium ion transport
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
JNK cascade
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of ATPase activity
vasodilation
calcium ion import
chemosensory behavior
anatomical structure morphogenesis
response to ischemia
apoptotic process
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
response to metal ion
response to organic cyclic compound
positive regulation of insulin secretion
cellular response to hepatocyte growth factor stimulus
positive regulation of vasoconstriction
branching morphogenesis of an epithelial tube
positive regulation of positive chemotaxis
response to calcium ion
regulation of calcium ion transport
fat pad development
cellular response to vitamin D
cellular response to glucose stimulus
cellular response to low-density lipoprotein particle stimulus
cellular response to hypoxia
response to fibroblast growth factor
positive regulation of calcium ion import
cellular response to peptide
signal transduction
