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Invitrogen
Carbonic Anhydrase IX Polyclonal Antibody
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Carbonic Anhydrase IX Antibody (PA5-111410) in IHC (P)
Immunohistochemistry analysis of Carbonic Anhydrase IX in human stomach and liver tissues. Samples were incubated with Carbonic Anhydrase IX polyclonal antibody (Product # PA5-111410). Corresponding CA9 RNA-seq data are presented for the same tissues.
产品信息
PA5-111410
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PCAQGVIWTV FNQTVMLSAK QLHTLSDTLW GPGDSRLQLN FRATQPLNGR VIEASFPAGV DSSPRAAEPV QLNSCL
Highest antigen sequence indentity to the following orthologs: Rat - 80%, Mouse - 80%.
靶标信息
Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CA-9; CA-IX; Carbonate dehydratase IX; Carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; Membrane antigen MN; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; Renal cell carcinoma-associated antigen G250
基因别名: CA9; CAIX; G250; MN
UniProt ID: (Human) Q16790
Entrez Gene ID: (Human) 768
