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NeoBiotechnologies
Clusterin/Apolipoprotein J (APO-J) (Marker of Anaplastic Large Cell Lymphoma) Recombinant Mouse Monoclonal Antibody (r7D1)
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Clusterin/Apolipoprotein J (APO-J) (Marker of Anaplastic Large Cell Lymphoma) Antibody (1191-MSM46-P1) in IHC (P)
Formalin-fixed, paraffin-embedded human adrenal gland stained with Clusterin Recombinant Mouse Monoclonal Antibody (r7D1). Inset: PBS instead of primary antibody; secondary only negative control.
产品信息
1191-MSM46-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
r7D1
抗原
Prokaryotic recombinant protein corresponding to a portion of the alpha subunit of the human clusterin molecule.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Cytoplasm, Secreted.
Positive control: Human pancreas, tonsil or cervix.
Tissue specificity: Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.
靶标信息
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aging associated protein 4; Aging-associated gene 4 protein; aging-associated protein 4; apo j; Apo J a; Apo J alpha; Apo J b; Apo J beta; Apo J α; Apo J β; Apo Ja; Apo Jb; Apo-J; ApoJ a; ApoJ alpha; ApoJ b; ApoJ beta; ApoJ α; ApoJ β; ApoJa; ApoJb; Apolipoprotein J; CLI; Clusterin; Clusterin alpha / beta chain; Complement associated protein SP40; Complement cytolysis inhibitor; complement lysis inhibitor; Complement-associated protein SP-40,40; GP80; HGNC:2095; Ku70-binding protein 1; Ku70-binding protein 1 (KUB1); MGC24903; NA1/NA2; SGP-2; Sulfated glycoprotein 2; Sulfated glycoprotein 2 (SGP2); Testosterone repressed prostate message 2 (TPRM2B); Testosterone-repressed prostate message 2; TRPM-2
基因别名: AAG4; APO-J; APOJ; CLI; CLU; CLU1; CLU2; KUB1; NA1/NA2; SGP-2; SGP2; SP-40; TRPM-2; TRPM2
UniProt ID: (Human) P10909
Entrez Gene ID: (Human) 1191
cell morphogenesis
microglial cell activation
release of cytochrome c from mitochondria
platelet degranulation
lipid metabolic process
complement activation
complement activation, classical pathway
aging
positive regulation of cell proliferation
response to light stimulus
response to wounding
response to virus
protein import
endocrine pancreas development
central nervous system myelin maintenance
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein homooligomerization
positive regulation of tumor necrosis factor production
response to potassium ion
reverse cholesterol transport
estrous cycle
innate immune response
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
neuron projection morphogenesis
protein stabilization
positive regulation of NF-kappaB transcription factor activity
chaperone-mediated protein complex assembly
response to misfolded protein
chaperone-mediated protein folding
microglial cell proliferation
cellular response to growth factor stimulus
regulation of beta-amyloid clearance
regulation of neuron death
positive regulation of neuron death
positive regulation of beta-amyloid formation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of beta-amyloid formation
regulation of neuronal signal transduction
positive regulation of tau-protein kinase activity
positive regulation of neurofibrillary tangle assembly
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
