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Invitrogen
Complement C3 Polyclonal Antibody
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Complement C3 Antibody (PA1-29715) in ICC/IF
ASN neuro 2022 -
Figure 7. Assessment of the functional state of reactive astrocytes after TMT exposure. Double immunofluorescent staining of GFAP and IL-1beta, TNF-alpha, IL-10, C3, iNOS and NF-kB and corresponding integrated fluorescence density expressed as AUs +- SEM in the injured CA area at 7 and 21 dpi. Significance shown inside the graphs: * p < .05 or less compared to age-match Ctrl. Note . AU = arbitrary unit; Ctr... View More
产品信息
PA1-29715
应用
建议稀释比
已发表文章
产品规格
种属反应
Baboon,
Horse,
Guinea pig,
Hamster,
Human,
Mouse,
Pig,
Rabbit,
Rat
已发表种属
C. elegans,
Cynomolgus monkey,
Guinea pig,
Human,
Mouse,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Human complement C3.
偶联物
形式
Liquid
浓度
89 mg/mL
保存液
50mM tris HCl, pH 7.5, with 500mM NaCl
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: Monospecific to human C3 complement component. This antibody has also been reported to recognize the C3 fragments, C3a, C3b and C3c.
Product is supplied as diluted unpurified antiserum. Store as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
C3 is a key component of the complement system since classical and alternative activation pathways merge at the C3 activation step when C3 is split into C3a and C3b. The molecular mass of C3 is 185 kDa and it consists of two chains (110 kDa and 75 kDa) held together by disulfide bonds.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: acylation-stimulating protein cleavage product; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a anaphylatoxin; Complement C3; complement C3 protein (GPC3) precursor; complement component 3; complement component C3; complement component C3 alpha-chain; complement component C3a; complement component C3b; epididymis secretory sperm binding protein Li 62p; HSE-MSF; prepro-C3
基因别名: AHUS5; AI255234; ARMD9; ASP; C3; C3a; C3b; C3d; CPAMD1; HEL-S-62p; HSE-MSF; I79_008227; Plp
UniProt ID: (Guinea pig) P12387, (Rat) P01026, (Human) P01024, (Mouse) P01027, (Pig) P01025
positive regulation of type IIa hypersensitivity
positive regulation of protein phosphorylation
positive regulation of activation of membrane attack complex
tolerance induction
fatty acid metabolic process
chemotaxis
inflammatory response
complement activation
complement activation, alternative pathway
complement activation, classical pathway
blood coagulation
positive regulation of vascular endothelial growth factor production
positive regulation of glucose transport
regulation of triglyceride biosynthetic process
positive regulation of lipid storage
negative regulation of endopeptidase activity
response to magnesium ion
response to estradiol
response to progesterone
response to estrogen
positive regulation of G-protein coupled receptor protein signaling pathway
positive regulation of angiogenesis
positive regulation of developmental growth
positive regulation of phagocytosis
response to glucocorticoid
positive regulation of ERK1 and ERK2 cascade
positive regulation of apoptotic cell clearance
proteolysis
immune response
signal transduction
G-protein coupled receptor signaling pathway
regulation of complement activation
regulation of immune response
innate immune response
