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Invitrogen
Complement C4b/C4c Polyclonal Antibody, FITC
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Complement C4b/C4c Antibody (PA1-28407)
Fig 3 Studies of ficolin-2 binding and ficolin-2-mediated complement deposition. A, ficolin-2 (FCN2) binds to representative serotype 11A, 35B, and 31 strains but not their isogenic O-acetyl transferase-deficient derivatives (11E, 35D, and 31X1). Bacteria were incubated with buffer (light gray fill), 10% heat-inactivated normal human serum (dark gray line), or 10% normal human serum (black line) for 1 hour ... View More
产品信息
PA1-28407
产品规格
种属反应
Human
已发表种属
C. elegans,
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
C4c complement isolated from complement activated human serum.
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
Conc. Not Determined
纯化类型
IgG fraction
保存液
PBS
内含物
0.09% sodium azide
保存条件
4°C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-28407 detects C4c / C4b from human samples.
Antigen retrieval for IHC (P): Proteinase K 30 min at 37°C
靶标信息
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; C4A2; C4A3; C4A4; C4A6; C4S; Chido form of C4; Complement C4-A; Complement C4-B; complement C4B1a; DAMC-258G8.6; MGC164979; RG
基因别名: C4A; C4B; C4B1; C4B12; C4B2; C4B3; C4B5; C4B_2; C4BD; C4F; CH; CO4; CPAMD2; CPAMD3
UniProt ID: (Human) P01028, (Human) P0C0L5
Entrez Gene ID: (Human) 721, (Human) 100293534
proteolysis
inflammatory response
complement activation
complement activation, classical pathway
opsonization
negative regulation of endopeptidase activity
regulation of complement activation
detection of molecule of bacterial origin
innate immune response
positive regulation of apoptotic cell clearance
