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Invitrogen
Cytokeratin 5/6/8/17/10 Monoclonal Antibody (MNF116)
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Cytokeratin 5/6/8/17/10 Antibody (MA1-26237) in ICC/IF
Immunofluorescence analysis of Cytokeratin Pan was performed using 70% confluent log phase A-431 cells. The cells were fixed and permeabilized with ice-cold acetone at 4°C for 5 minutes and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Cytokeratin Pan Monoclonal Antibody (MNF116) (Product # MA1-26237, 1:100 dilution) in 0.1% BSA, incubated at 4 degree celsius overnight and ... View More
产品信息
MA1-26237
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
MNF116
抗原
Crude extract of splenic cells from a nude mouse engrafted with MCF-7 cells.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
tissue culture supernatant
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: Skin.
This antibody reacts Cytokeratin 5, Cytokeratin 6, Cytokeratin 8, Cytokeratin 17 and Cytokeratin 19.
靶标信息
Cytokeratins (CKs) are intermediate filament proteins essential for the structural integrity and function of epithelial cells. They are categorized into various types based on their distribution and expression patterns. CK5 is primarily expressed in basal epithelial cells, particularly in the breast, and serves as a marker for basal-like breast carcinomas. CK6, though functionally distinct from CK5, is often studied concurrently due to its expression in squamous cell types and squamous cell carcinomas. CK8 is a marker for luminal epithelial cells and is predominantly expressed in various carcinomas, including hepatocellular carcinoma. CK17 is associated with the basal-like phenotype in certain cancers, notably correlating with poor prognosis in breast cancer and the BRCA1 mutation. CK10 is typically expressed in keratinizing squamous epithelium and is pivotal in skin differentiation. Understanding the differential expression of these cytokeratins aids in the histological diagnosis and prognosis of epithelial carcinomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
