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Invitrogen
Cytokeratin Pan Type II Monoclonal Antibody (AE3)
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产品信息
MA1-5762
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Chicken,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
AE3
抗原
Human epidermal keratins from P3 x 63 Ag8 cells
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-5762 reacts with all basic (type II) human keratins in human samples, including K1, K2, K3, K4, K5, K6, K7 and K8.
MA1-5762 has been successfully used in Western blot, immunohistochemistry and electron microscopy procedures.
The MA1-5762 immunogen is human epidermal keratins.
靶标信息
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; alpha keratin; CK 2e; CK-1; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-72; CK-8; cytokeratin 1; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; Cytokeratin endo A; Cytokeratin otokeratin; cytokeratin type II, component Ia; cytokeratin type II, component Ib/c; cytokeratin type II, component III; Cytokeratin-1; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; Cytokeratin-7; Cytokeratin-72; Cytokeratin-8; Cytokeratin-A; Cytoskeletal 57 kDa keratin; ear specific cytokeratin; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; Epithelial keratin-2e; Hair alpha protein; K1; K2e; K2P; K3; K3 keratin; K4; K5; K6A; K7; K72; K76; K8; kamp-keratin derived antimicrobial peptide; KDAMP; KERA; keratin 1, type II; keratin 2 (epidermal ichthyosis bullosa of Siemens); keratin 2 epidermis; keratin 2, type II; keratin 2A; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6 alpha; keratin 6, inner root sheath, 2; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 72, pseudogene; keratin 72, type II; keratin 76, type II; keratin 8, type II; keratin 86; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 35; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; keratin IV; keratin K3; keratin K6h; keratin protein K6irs; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 59 kDa, component IV; keratin, type II cytoskeletal 60 kDa, component III; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 72; Keratin, type II cytoskeletal 8; Keratin, type II cytoskeletal cochleal; Keratin-1; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6-alpha; Keratin-6A; keratin-6C; Keratin-7; Keratin-72; Keratin-76; Keratin-8; krt1 {ECO:0000250|UniProtKB:P04264}; krt2; krt2 {ECO:0000250|UniProtKB:P35908}; krt4 {ECO:0000250|UniProtKB:P19013}; krt5; krt7; krt7 {ECO:0000250|UniProtKB:P08729}; krt76; MGC116967; MGC116968; mK6-alpha; otokeratin; pan keratin; Sarcolectin; tuftelin interacting protein 8; type II alpha-keratin IIA; type II alpha-keratin IIC; type II cytokeratin A (no.8); type II cytoskeletal cochleal; Type II inner root sheath-specific keratin-K6irs2; type II keratin Kb1; type II keratin Kb2; type II keratin Kb35; type II keratin Kb4; type II keratin Kb7; type II keratin Kb9; type II mesothelial keratin K7; Type-II keratin Kb1; type-II keratin Kb12; Type-II keratin Kb2; Type-II keratin Kb3; Type-II keratin Kb35; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9; type-II keratin-35
基因别名: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; AA960620; AI507495; AL022697; AU019895; AW108092; AW146334; BB005427; CARD2; CK-2e; CK-3; CK-4; CK-6C; CK-6E; CK-8; CK1; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK4; CYK8; CYKER; D15Wsu77e; DDD; DDD1; EBS2; EHK; EHK1; EndoA; EPPK; HUMCYT2A; K1; K2C7; K2C8; K2e; K3; K4; K5; K6A; K6C; K6D; K6irs; K6IRS2; K7; K8; Kb1; Kb2; KB35; Kb4; Kb7; Kb9; Ker2; keratin; KERIA; KERIB; KO; Krt-2.1; Krt-2.4; Krt-2.8; KRT1; KRT1A; KRT2; Krt2-1; Krt2-17; Krt2-2; Krt2-35; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; KRT2-8; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; KRT5A; KRT6; KRT6A; KRT6C; KRT6D; KRT6IRS2; KRT7; KRT72; Krt72-ps; KRT76; KRT8; Krt86; KRTA; KRTE; mK6[a]; MK6a; NEPPK; PC3; Sak57; SCL; Tfip8; WSN1
UniProt ID: (Human) P86104, (Human) P35908, (Human) P12035, (Rabbit) Q29426, (Human) P19013, (Bovine) Q5XQN5, (Human) P13647, (Human) P02538, (Human) P08729, (Chicken) O93532, (Bovine) Q29S21, (Bovine) Q148H8, (Human) Q14CN4, (Human) Q01546, (Bovine) P05786, (Human) P05787, (Rat) Q6IMF3, (Mouse) P04104, (Mouse) Q3TTY5, (Rat) Q6IG02, (Mouse) P07744, (Rat) Q6IG00, (Rat) Q6P6Q2, (Mouse) Q922U2, (Mouse) P50446, (Mouse) Q9DCV7, (Rat) Q6IG12, (Mouse) Q6IME9, (Rat) Q6IG04, (Mouse) Q3UV17, (Rat) Q10758, (Mouse) P11679
Entrez Gene ID: (Rabbit) 100353415, (Human) 3848, (Pig) 100049664, (Rabbit) 100353162, (Human) 3849, (Pig) 100049665, (Human) 3850, (Bovine) 407188, (Rabbit) 100353668, (Pig) 100157304, (Bovine) 527819, (Human) 3851, (Pig) 100157675, (Rabbit) 100348388, (Pig) 100511564, (Bovine) 281268, (Human) 3852, (Chicken) 407779, (Rabbit) 100352658, (Bovine) 614456, (Pig) 102164968, (Chicken) 408041, (Human) 3853, (Human) 3855, (Chicken) 395772, (Rabbit) 100345579, (Bovine) 535697, (Bovine) 531057, (Human) 140807, (Human) 51350, (Bovine) 407189, (Rabbit) 100348891, (Bovine) 281269, (Human) 3856, (Chicken) 426896, (Pig) 100152077, (Rat) 300250, (Mouse) 16678, (Mouse) 16681, (Rat) 406228, (Mouse) 16682, (Rat) 315323, (Rat) 369017, (Mouse) 110308, (Mouse) 16687, (Mouse) 110310, (Rat) 300242, (Mouse) 105866, (Rat) 406227, (Rat) 407757, (Mouse) 77055, (Rat) 25626, (Mouse) 16691
epithelial cell differentiation
intermediate filament cytoskeleton organization
complement activation, lectin pathway
retina homeostasis
biological_process
negative regulation of inflammatory response
establishment of skin barrier
viral process
cytoskeleton organization
negative regulation of epithelial cell proliferation
epidermis development
sebaceous gland development
tumor necrosis factor-mediated signaling pathway
sarcomere organization
response to hydrostatic pressure
response to other organism
cell differentiation involved in embryonic placenta development
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
hemidesmosome assembly
response to oxidative stress
fibrinolysis
regulation of angiogenesis
intermediate filament-based process
embryo development
hair follicle morphogenesis
keratinization
keratinocyte activation
keratinocyte proliferation
intermediate filament organization
keratinocyte migration
cell morphogenesis involved in differentiation
multicellular organism development
morphogenesis of an epithelium
Wnt signaling pathway
wound healing
