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Invitrogen
DGKI Polyclonal Antibody
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产品信息
PA5-54539
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: IRVNKISLQD YEGFHYDKEK LREASIPLGI LVVRGDCDLE TCRMYIDRLQ EDLQSVSSGS QRVHYQDHET
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 97%.
靶标信息
Diacylglycerol (DAG) influences numerous cell signaling cascades by functioning as an intracellular, allosteric activator of protein kinase C (PKC), and as a potent activator of guanine nucleotide exchange factors. In order to maintain cellular homeostasis, intracellular DAG levels are tightly regulated by diacylglycerol kinases (DGKs, DAGKs), which phosphorylate DAG to phosphatidic acid, thus removing DAG. Human DGK-α (80 kDa), -β (90 kDa), and - γ (90 kDa) have calcium-binding EF-hand motifs at their N termini and are classified as type I DGKs. Human DGK-δ (130 kDa) and DGK-ι (130 kDa) contain N-terminal pleckstrin homology (PH) domains and are classified as type II. Human DGK-epsilon (64 kDa) contains no identifiable regulatory domains and is classified as a type III DGK. Human DGK-Ω (104 kDa) and -iota (130 kDa) possess C-terminal ankyrin repeats and are classified as type IV DGKs. Human DGK-θ (110 kDa) contains 3 cysteine-rich domains and a PH domain and is classified as a type V DGK.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAG kinase iota; Diacylglycerol kinase iota; diacylglycerol kinase, iota; Diglyceride kinase; diglyceride kinase iota; EC 2.7.1.107
基因别名: DGK-IOTA; DGKI
UniProt ID: (Human) O75912
Entrez Gene ID: (Human) 9162
protein kinase C-activating G-protein coupled receptor signaling pathway
neurotransmitter secretion
phosphorylation
platelet activation
negative regulation of GTPase activity
intracellular signal transduction
positive regulation of Ras protein signal transduction
habituation
regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
regulation of long term synaptic depression
