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Invitrogen
DKK1 Recombinant Rabbit Monoclonal Antibody (SC06-86)
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产品信息
MA5-32229
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
SC06-86
抗原
Synthetic peptide within Human DKK1 aa 225-266.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: dickkopf 1 homolog; dickkopf homolog 1; Dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; Dickkopf-related protein 1; Dickkopf1; hDkk1; secreted wnt inhibitor with affinity for heparin sepharose; SK; unnamed protein product
基因别名: DKK-1; DKK1; SK; UNQ492/PRO1008
UniProt ID: (Human) O94907
Entrez Gene ID: (Human) 22943, (Rat) 293897
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
endoderm formation
mesoderm formation
hair follicle development
regulation of receptor internalization
heart induction
heart valve development
endocardial cushion development
endoderm development
learning or memory
positive regulation of gene expression
negative regulation of neuron projection development
Wnt signaling pathway
regulation of Wnt signaling pathway
negative regulation of Wnt signaling pathway
negative regulation of ossification
embryonic limb morphogenesis
negative regulation of BMP signaling pathway
forebrain development
response to retinoic acid
negative regulation of mesodermal cell fate specification
regulation of endodermal cell fate specification
negative regulation of apoptotic process
regulation of neuron apoptotic process
positive regulation of Wnt signaling pathway, calcium modulating pathway
positive regulation of JNK cascade
regulation of synapse organization
regulation of synaptic transmission, glutamatergic
canonical Wnt signaling pathway
limb development
head morphogenesis
face morphogenesis
negative regulation of SMAD protein import into nucleus
motor learning
negative regulation of canonical Wnt signaling pathway
Wnt signaling pathway involved in somitogenesis
synapse pruning
regulation of dopaminergic neuron differentiation
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly
positive regulation of midbrain dopaminergic neuron differentiation
negative regulation of presynapse assembly
positive regulation of Wnt signaling pathway, planar cell polarity pathway
negative regulation of cardiac muscle cell differentiation
multicellular organism development
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