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Abnova
DNMBP Polyclonal Antibody, MaxPab™
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产品信息
H00023268-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DNMBP (AAH41628.1, 1 a.a. approximately 823 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTLLSSQSSS LVAPSGSVSA ENPEQRMLEK RAKVIEELLQ TERDYIRDLE MCIERIMVPM QQAQVPNIDF EGLFGNTQMV IKVSKQLLAA LEISDAVGPV FLGHRDELEG TYKIYCQNHD EAIALLEIYE KDEKIQKHLQ DSLADLKSLY NEWGCTNYIN LGSFLIKPVQ RVMRYPLLLM ELLNSTPESH PDKVPLTNAV LAVKEINVNI NEYKRRKDLV LKYRKGDEDS LMEKISKLNI HSIIKKSNRV SSHLKHLTGF APQIKDEVFE ETEKNFRMQE RLIKSFIRDL SLYLQHIRES ACVKVVAAVS MWDVCMERGH RDLEQFERVH RYISDQLFTN FKERTERLVI SPLNQLLSMF TGPHKLVQKR FDKLLDFYNC TERAEKLKDK KTLEELQSAR NNYEALNAQL LDELPKFHQY AQGLFTNCVH GYAEAHCDFV HQALEQLKPL LSLLKVAGRE GNLIAIFHEE HSRVLQQLQV FTFFPESLPA TKKPFERKTI DRQSARKPLL GLPSYMLQSE ELRASLLARY PPEKLFQAER NFNAAQDLDV SLLEGDLVGV IKKKDPMGSQ NRWLIDNGVT KGFVYSSFLK PYNPRRSHSD ASVGSHSSTE SEHGSSSPRF PRQNSGSTLT FNPSSMAVSF TSGSCQKQPQ DASPPPKEWD QGTLSASLNP SNSESSPSRC PSDPDSTSQP RSGDSADVAR DVKQPTATPR SYRNFRHPEI VGYSVPGRNG QSQDLVKGCA RTAQAPEDRS TEPDGSEAEG NQVYFAVYTF KARNPNELSV SANQKLKILE FKDVTGNTEW WLAEVNGKKG YVPSNYIRKT EYT
靶标信息
The Dynamin Binding Protein (DNMBP) gene is located on chromosome 10 and has been implicated in Alzheimer's disease due to its role in regulating the actin cytoskeleton and synaptic vesicle pools, which are critical for proper neuronal function and memory performance. DNMBP mRNA expression levels are shown to be lower in Alzheimer's brains, suggesting its potential role in cognitive decline. Genetic studies have linked DNMBP to late-onset Alzheimer's disease (AD) through its single nucleotide polymorphisms (SNPs) such as rs11190305 and rs3740058, although the results show variability across different ethnic populations regarding its association with AD risk. Additionally, research on aged rats demonstrated a correlation between DNMBP expression and long-term memory performance, indicating its significance in maintaining cognitive functions during aging.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dynamin-binding protein; Scaffold protein Tuba
基因别名: ARHGEF36; DNMBP; KIAA1010; TUBA
UniProt ID: (Human) Q6XZF7
Entrez Gene ID: (Human) 23268
