Search Thermo Fisher Scientific
图: 1 / 1
In direct ELISAs, less than 3% cross-reactivity with recombinant human (rh) DOCK1, rhDOCK2, and rhDOCK5 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Dedicator of cytokinesis3 (DOCK3), also named as MOCA and PBP, is a ~180 kDa protein involved in signaling transduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3beta (GSK-3beta) at the plasma membrane, thereby promoting axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Dedicator of cytokinesis protein 3; dok-3; Modifier of cell adhesion; PBP; Presenilin-binding protein
基因别名: DOCK3; KIAA0299; MOCA; PBP
UniProt ID: (Human) Q8IZD9
Entrez Gene ID: (Human) 1795
分子生物学功能: guanyl-nucleotide exchange factor