Invitrogen

Dystrophin Polyclonal Antibody

7个已发表图片
23 篇参考文献
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说明书
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Dystrophin Polyclonal Antibody

产品信息

PA5-32388

应用
建议稀释比
已发表文章

免疫印迹 (WB)

-
查看3篇已发表文章 3篇已发表文章

免疫组化 (IHC)

-
查看12篇已发表文章 12篇已发表文章

免疫组化（石蜡） (IHC (P))

1:100
-

免疫组织化学（多聚甲醛固定） (IHC (PFA))

-
查看1篇已发表文章 1篇已发表文章

免疫组化（冰冻） (IHC (F))

1:400
查看4篇已发表文章 4篇已发表文章

免疫细胞化学 (ICC/IF)

-
查看3篇已发表文章 3篇已发表文章
产品规格

种属反应

Human, Mouse

已发表种属

Bovine, C. elegans, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide derived from C-terminus of human dystrophin.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.6, with 1% BSA

内含物

0.1% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2549858

产品详细信息

This antibody is predicted to react with bovine, chicken, canine and porcine based on sequence homology.

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is skeletal muscle tissue.

靶标信息

Dystrophin is the 427kDa protein product of the DMB/BMD gene located on the X chromosome at position Xp21. Western blotting and immunohistochemistry are the two established methods for the detection of abnormalities of dystrophin expression in muscle biopsies. Dystrophin abnormalities are thought to occur in 100% of patients with DMD/BMD, although genetic abnormalities may only be detected in up to 65% of cases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Duchenne muscular dystrophy (DMD); Dystrophin; dystrophin Dp40; dystrophin Dp71a; dystrophin Dp71ab; dystrophin Dp71b; GS1-19O24.1; Muscular dystrophy Duchenne and Becker types; OTTHUMP00000215592; X-linked muscular dystrophy

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基因别名: BMD; CMD3B; DMD; Dp427; Dp71; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; DXSmh7; DXSmh9; dys; mdx; MRX85; pke

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UniProt ID: (Human) P11532, (Mouse) P11531

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Entrez Gene ID: (Human) 1756, (Mouse) 13405

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功能
dystroglycan binding actin binding structural constituent of cytoskeleton protein binding zinc ion binding structural constituent of muscle myosin binding vinculin binding nitric-oxide synthase binding metal ion binding ubiquitin-protein ligase
参与通路
regulation of heart rate cytoskeleton organization muscle organ development regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of skeletal muscle contraction muscle attachment muscle filament sliding negative regulation of peptidyl-serine phosphorylation cellular protein localization response to muscle stretch peptide biosynthetic process cellular protein complex assembly muscle cell cellular homeostasis muscle fiber development cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity cardiac muscle cell action potential regulation of voltage-gated calcium channel activity negative regulation of peptidyl-cysteine S-nitrosylation positive regulation of sodium ion transmembrane transporter activity positive regulation of cell-matrix adhesion regulation of transcription, DNA-templated skeletal muscle tissue development establishment of blood-nerve barrier regulation of gene expression positive regulation of neuron projection development myotube cell development olfactory nerve structural organization regulation of membrane potential neurotransmitter receptor metabolic process positive regulation of neuron differentiation nucleus localization establishment of glial blood-brain barrier negative regulation of ERK1 and ERK2 cascade regulation of cellular response to growth factor stimulus
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