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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Endothelin 1 Antibodies

          Abnova

          EDN1 Monoclonal Antibody (3D6)

          查看其他11个Endothelin 1抗体

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          Cite EDN1 Monoclonal Antibody (3D6)

          • 抗体检测数据 (3)
          EDN1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          EDN1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          图: 1 / 3

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          EDN1 Antibody (H00001906-M01) in WB

          Western Blot analysis of EDN1 expression in transfected 293T cell line by EDN1 monoclonal antibody (M01), clone 3D6.

          Lane 1: EDN1 transfected lysate(24 KDa).
          Lane 2: Non-transfected lysate.
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          EDN1 Antibody in Western Blot (WB)
          EDN1 Antibody in Immunoprecipitation (IP)
          EDN1 Antibody in ELISA (ELISA)
          EDN1 Monoclonal Antibody (3D6)

          产品信息

          H00001906-M01

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1-5 µg/mL
          -

          酶联免疫吸附实验 (ELISA)

          0.3 ng/mL
          -

          免疫沉淀 (IP)

          1-5 µg/mL
          -
          产品规格

          种属反应

          Human

          宿主/亚型

          Mouse / IgG2a, kappa

          分类

          Monoclonal

          类型

          Antibody

          克隆号

          3D6

          抗原

          EDN1 (AAH09720, 113 a.a. approximately 212 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          See Label

          纯化类型

          Affinity chromatography

          保存液

          PBS, pH 7.4

          内含物

          no preservative

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles

          运输条件

          Ambient (domestic); Wet ice (international)

          产品详细信息

          Sequence of this protein is as follows: SQKDKKCWNF CQAGKELRAE DIMEKDWNNH KKGKDCSKLG KKCIYQQLVR GRKIRRSSEE HLRQTRSETM RNSVKSSFHD PKLKGNPSRE RYVTHNRAHW

          靶标信息

          The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: Big endothelin 1; Big ET; Big ET 1; Big ET1; BigET; Endothelin-1; Et; PPET1; Preproendothelin-1

          查看更多 收起

          基因别名: ARCND3; EDN1; ET1; HDLCQ7; PPET1; QME

          查看更多 收起

          UniProt ID: (Human) P05305

          查看更多 收起

          Entrez Gene ID: (Human) 1906

          查看更多 收起

          功能
          cytokine activity hormone activity protein binding endothelin A receptor binding endothelin B receptor binding peptide hormone
          参与通路
          negative regulation of transcription from RNA polymerase II promoter prostaglandin biosynthetic process patterning of blood vessels in utero embryonic development histamine secretion regulation of systemic arterial blood pressure by endothelin regulation of pH cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway cell-cell signaling heart development respiratory gaseous exchange body fluid secretion positive regulation of cell proliferation dorsal/ventral pattern formation response to ozone multicellular organism aging positive regulation of heart rate positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy positive regulation of receptor biosynthetic process neural crest cell development phosphatidylinositol 3-kinase signaling response to activity artery smooth muscle contraction vein smooth muscle contraction glucose transport cell growth regulation of vasoconstriction sensory perception of pain calcium-mediated signaling peptide hormone secretion nitric oxide transport negative regulation of blood coagulation positive regulation of cell migration neutrophil chemotaxis negative regulation of cAMP biosynthetic process phospholipase D-activating G-protein coupled receptor signaling pathway negative regulation of cellular protein metabolic process positive regulation of prostaglandin secretion response to lipopolysaccharide response to testosterone negative regulation of smooth muscle cell apoptotic process response to prostaglandin F response to nicotine cellular response to drug positive regulation of urine volume positive regulation of renal sodium excretion response to muscle stretch epithelial fluid transport vasoconstriction protein kinase C deactivation middle ear morphogenesis positive regulation of odontogenesis superoxide anion generation rhythmic excitation response to amino acid positive regulation of MAP kinase activity positive regulation of JUN kinase activity response to leptin leukocyte activation positive regulation of nitric oxide biosynthetic process positive regulation of cell size positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle contraction positive regulation of hormone secretion negative regulation of hormone secretion inositol phosphate-mediated signaling positive regulation of smooth muscle cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity cartilage development positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway negative regulation of nitric-oxide synthase biosynthetic process membrane depolarization regulation of sensory perception of pain maternal process involved in parturition positive regulation of sarcomere organization positive regulation of prostaglandin-endoperoxide synthase activity positive regulation of cell growth involved in cardiac muscle cell development positive regulation of chemokine-mediated signaling pathway cellular response to calcium ion cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to peptide hormone stimulus cellular response to glucocorticoid stimulus cellular response to mineralocorticoid stimulus cellular response to fatty acid cellular response to hypoxia response to dexamethasone cellular response to transforming growth factor beta stimulus response to salt
          It has to be done as per old AB suggested Products section.
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