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Invitrogen
EphA1 Polyclonal Antibody
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产品信息
PA5-79210
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human Eph receptor A1 (963-976aa HQKRILCSIQGFKD).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human Colo320 whole cell, human HepG2 whole cell, human Caco-2 whole cell, rat brain tissue, rat lung tissue, mouse brain tissue, mouse lung tissue. IHC: Rat Brain Tissue, Human Colon Cancer Tissue.
靶标信息
EphA1 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EphA1 is expressed in some human cancer cell lines and has been implicated in carcinogenesis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Embryonic stem cell kinase; EPH tyrosine kinase; EPH tyrosine kinase 1; ephrin receptor EphA1; Ephrin type-A receptor 1; erythropoietin-producing hepatoma amplified sequence; Erythropoietin-producing hepatoma receptor; hEpha1; mEpha1; MGC163163; oncogene EPH; soluble EPHA1 variant 1; soluble EPHA1 variant 2; Tyrosine-protein kinase receptor EPH; Tyrosine-protein kinase receptor ESK
基因别名: 5730453L17Rik; AL033318; EPH; EPHA1; EPHT; EPHT1; Esk
UniProt ID: (Human) P21709, (Mouse) Q60750
Entrez Gene ID: (Human) 2041, (Mouse) 13835, (Rat) 312279
protein kinase activity
transmembrane-ephrin receptor activity
ATP binding
protein kinase binding
nucleotide binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
angiogenesis
positive regulation of cell-matrix adhesion
negative regulation of protein kinase activity
cell surface receptor signaling pathway
positive regulation of cell proliferation
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
negative regulation of cell migration
substrate adhesion-dependent cell spreading
somatic stem cell population maintenance
regulation of GTPase activity
positive regulation of angiogenesis
protein autophosphorylation
ephrin receptor signaling pathway
positive regulation of stress fiber assembly
activation of GTPase activity
protein phosphorylation
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
phosphorylation
