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Immunogen sequence: LSLRQPGLAE AVCVKFLEDA LGQKLPRRPQ PGPGEQLTVF QFWSFVETLD SPTMEAYVTE TAEEVLLVRN LNSDDQAVVL KALRLAPEGR LRRDGLRALS SLLVHGNNKV MAAVSTQLRS LSLGPTFRER ALLCFLDQLE DEDVQTRVAG CLALGCIKAP EGIEPLVYLC QTDTEAVREA ARQSLQQCGE EGQSAHRRLE ESLDALPRIF GPGSMASTAF; Positive Samples: Mouse kidney; Cellular Location: Cytoplasm
Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ13725; protein FAM65A; Rho family-interacting cell polarization regulator 1
基因别名: 2310066E14Rik; AI837433; Fam65a; Kiaa1930; Ripor1
UniProt ID: (Mouse) Q68FE6
Entrez Gene ID: (Mouse) 75687