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Invitrogen
FGD1 Polyclonal Antibody
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产品信息
PA5-85408
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human FGD1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (98%), Rat (98%), Bovine (100%).
Positive Control: Target recombinant protein, U87-MG, SK-N-SH, IMR32, SK-N-AS.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Faciogenital dysplasia 1 protein; FYVE, RhoGEF and PH domain-containing protein 1; Rho/Rac GEF; Rho/Rac guanine nucleotide exchange factor FGD1; Zinc finger FYVE domain-containing protein 3
基因别名: AAS; FGD1; FGDY; MRXS16; ZFYVE3
UniProt ID: (Human) P98174
Entrez Gene ID: (Human) 2245
cytoskeleton organization
signal transduction
multicellular organism development
regulation of cell shape
organ morphogenesis
actin cytoskeleton organization
regulation of Rho protein signal transduction
positive regulation of apoptotic process
regulation of GTPase activity
positive regulation of GTPase activity
filopodium assembly
regulation of small GTPase mediated signal transduction
