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Invitrogen
FGD4 Polyclonal Antibody
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FGD4 Antibody (PA5-121213) in WB
Western blot analysis of FGD4 in extracts of various cell lines. Samples were incubated with FGD4 Polyclonal antibody (Product # PA5-121213) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
产品信息
PA5-121213
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 99-198 of human FGD4 (NP_640334.2).
偶联物
形式
Liquid
浓度
2.58 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: U-87MG, HeLa, HepG2, A-549, Rat brain. The target is usually found in the following locations: Cell projection, Cytoplasm, cytoskeleton, filopodium.
Immunogen sequence: QMECEEEKAA TLSSDTSIQA SEPLLDTHIV NGERDETATA PASPTTDSCD GNASDSSYRT PGIGPVLPLE ERGAETETKV QERENGESPL ELEQLDQHHE
靶标信息
The FGD4 gene, also known as FYVE, RhoGEF, and PH domain-containing protein 4, is located on chromosome 12p11.21. This gene encodes a protein involved in the regulation of the actin cytoskeleton and is crucial for cellular processes such as migration and adhesion. FGD4 is specifically associated with Charcot-Marie-Tooth disease type 4H (CMT4H), a rare autosomal recessive hereditary neuropathy characterized by early onset, progressive distal muscle weakness, scoliosis, and myelin outfoldings. Mutations in FGD4 result in disruptions of its function, leading to the clinical manifestations of CMT4H. Additionally, the gene has been implicated in cancer biology, with its expression correlating with aggressive phenotypes in some cancers and contributing to therapeutic resistances. The gene includes multiple exons and alternative splicing variants, underlining its broad functional implications.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Actin filament-binding protein frabin; actin-filament binding protein frabin; FGD1 family, member 4; FGD1-related F-actin-binding protein; FYVE, RhoGEF and PH domain-containing protein 4; Zinc finger FYVE domain-containing protein 6
基因别名: 9030023J02Rik; 9330209B17Rik; CMT4H; FGD4; FRABP; ZFYVE6
UniProt ID: (Human) Q96M96, (Mouse) Q91ZT5
Entrez Gene ID: (Human) 121512, (Rat) 246174, (Mouse) 224014
cytoskeleton organization
regulation of cell shape
actin cytoskeleton organization
regulation of Rho protein signal transduction
positive regulation of apoptotic process
regulation of GTPase activity
positive regulation of GTPase activity
filopodium assembly
regulation of small GTPase mediated signal transduction
activation of JUN kinase activity
lamellipodium assembly
microspike assembly
