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Invitrogen
FICD Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-67147
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.05 mg/mL
规格
5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: VKKVMSIPKGN SALRRVMEET YYHHIYHTVA IEGNTLTLSE IRHILETRYA VPGKSLEEQN EVIGMHAAMK YINTTLVSRI GSVTISD
Highest antigen sequence identity to the following orthologs - mouse 97%, rat 93%.
靶标信息
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it. In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity. Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adenosine monophosphate-protein transferase FICD; AMPylase; AMPylator FICD; de-AMPylase FICD; FIC domain containing; FIC domain-containing protein; fic S-phase protein cell division homolog; HIP-13; Huntingtin interacting protein E; huntingtin interactor protein E; huntingtin yeast partner E; huntingtin-interacting protein 13; huntingtin-interacting protein E; MGC5623
基因别名: HIP13; HYPE; SPG92; UNQ3041
UniProt ID: (Human) Q9BVA6
Entrez Gene ID: (Human) 11153
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