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Bethyl Laboratories
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The FLG2 protein is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. FLG2 is also required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Filaggrin-2; FLG-2; Ifapsoriasin; intermediate filament-associated and psoriasis susceptibility protein; Intermediate filament-associated and psoriasis-susceptibility protein
基因别名: FLG2; IFPS
UniProt ID: (Human) Q5D862
Entrez Gene ID: (Human) 388698